Self assembling molecules for targeted drug delivery
AssigneeThe General Hospital Corporation
InventorsDavid R. Elmaleh, Kazue Takahashi
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Abstract
Described herein are self-assembling protein molecules for delivering a payload, for example, a toxic anti-cancer agent, a cancer immunotherapy, a toxic anti-cancer agent and a cancer immunotherapy, or an imaging agent, to specific tissues. Examples of self-assembled proteins include clathrin and derivatives of clathrin.
Claims36
A first composition comprising a protein, a first payload, and a first targeting agent, wherein the protein is in the form of a three-dimensional cage structure comprising an outer surface and an inner cavity;
- and the first targeting agent is conjugated to the outer surface of the three-dimensional cage structure.
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A second composition comprising a protein, a second payload, and a second targeting agent, wherein the protein is in the form of a three-dimensional cage structure comprising an outer surface and an inner cavity;
- the second payload is an immunogen;
- and the second targeting agent conjugated to the outer surface of the three-dimensional cage structure.
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Dependencies are inferred from the claim text.