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US 2018/0140575 A1Published application
Use of alpha-hydroxy carbonyl compounds as reducing agents
AssigneeMorvus Technology Limited
InventorRichard J. KNOX
Life of this patent
Estimating the term…
Abstract
There is provided the use as reducing agents of alpha-hydroxycarbonyl compounds capable of forming cyclic dimers. There is also provided corresponding methods of reducing reducible compounds, particularly reduction-activated prodrugs. Examples of the alpha-hydroxycarbonyl compounds used are dihydroxyacetone, glycolaldehyde, glyceraldehyde, erythrose, xylulose, erythrulose or 3-hydroxy-2-butanone.
Claims9
1-72. (canceled)
73:
- A topical pharmaceutical composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a topically-acceptable adjuvant, diluent or carrier.
74:
- The topical pharmaceutical composition according to claim 73, wherein the composition is a solution or suspension.
75:
- The topical pharmaceutical composition according to claim 74, wherein the solution or suspension is sprayable.
76:
- The topical pharmaceutical composition according to claim 73, wherein the composition is a cream, lotion or ointment.
77:
- A dry powder aerosol composition comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide.
78:
- A therapeutic system comprising:
- (a) a dry powder inhalation device, and
- (b) one or more discrete doses of the dry powder aerosol composition according to claim 77.
79:
- The therapeutic system according to claim 78, wherein the dry powder inhalation device contains a source of propellant gas.
80:
- A device that is:
- (a) a mechanical sprayer having a reservoir loaded with a solution or suspension comprising 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier;
- or
- (b) an aerosol device comprising a solution or suspension comprising one or more propellant gases and 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide and a pharmaceutically-acceptable adjuvant, diluent or carrier.
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