Insertable variable fragments of antibodies and modified alpha1-alpha2 domains of nkg2d ligands, and non-natural nkg2d ligands that bind non-natural nkg2d receptors
AssigneeAvidBiotics Corp.
InventorsKyle LANDGRAF, Daniel P. STEIGER, Tarah Baron, Dana Gebhart
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Abstract
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands.
Claims20
A non-natural, modified α1-α2 domain of a natural NKG2D ligand molecule comprising at least 80% identity to the natural α1-α2 domain, wherein the modified α1-α2 domain has one or more amino acids of the natural α1-α2 domain replaced and wherein the modification increases its binding affinity to a non-natural NKG2D receptor ectodomain, wherein the ectodomain of the non-natural NKG2D receptor has an affinity for natural NKG2D ligands that is less than the affinity of the natural NKG2D receptor ectodomain for the natural NKG2D ligands.
Dependencies are inferred from the claim text.