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AssigneeTakeda Vaccines, Inc.
InventorsSubash Chandra DAS, Joseph David SANTANGELO, Dan Thomas STINCHCOMB, Jorge E. OSORIO
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The present disclosure relates to hand, foot, and mouth disease vaccines and immunogenic compositions having one or more antigens from at least one virus that causes hand, foot, and mouth disease in humans, and methods of manufacture, formulation, and testing, and uses thereof. Thus, there is a need to develop vaccines and immunogenic compositions for treating and/or preventing hand, food, and mouth disease, particularly in children. In order to meet this need, the present disclosure provides vaccines and immunogenic compositions for treating and/or preventing hand, foot, and mouth disease that include antigens from at least one virus that causes hand, foot, and mouth disease in humans, such as EV71, CA6, and CA16.
A hand, foot, and mouth immunogenic composition or vaccine comprising one or more antigens from at least one virus that causes hand, foot and mouth disease in humans, wherein the one or more antigens comprise at least one non-human cell adaptation mutation.
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A hand, foot, and mouth immunogenic composition or vaccine comprising one or more antigens from at least one inactivated virus that causes hand, foot and mouth disease in humans, wherein the at least one virus is EV71, and wherein the at least one virus was inactivated with beta-propiolactone (BPL).
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A method for inactivating a hand, foot, and mouth virus preparation, comprising:
A method for inactivating a hand, foot, and mouth virus preparation, comprising:
Dependencies are inferred from the claim text.