Method and system for microbiome-derived characterization, diagnostics, and therapeutics for cardiovascular disease conditions

A method for characterizing and treating a cardiovascular condition for a subject, the method comprising:

• providing a set of sampling kits to at least a subject of a set of subjects including subjects exhibiting the cardiovascular condition, each sampling kit of the set of sampling kits comprising a sample container and a pre-process reagent component, wherein the sample container is operable to receive a sample;
• receiving a set of samples from the set of sampling kits, the set of samples comprising a microorganism component;
• identifying a primer set for a nucleic acid sequence set associated with the microorganism component;
• with amplification substrates of a next generation sequencing platform of a sample processing system, determining a set of microorganism nucleic acid sequences based on the set of samples and the primer set;
• generating a microbiome feature dataset for the set of subjects based on the set of microorganism nucleic acid sequences;
• generating a characterization of the cardiovascular condition based on the microbiome feature dataset;
• determining a therapy for the subject based on the characterization and a sample from the subject, wherein the therapy is operable to improve a state of the cardiovascular condition;
• and
• providing the therapy to the subject with the cardiovascular condition, wherein the therapy is operable to modulate microbiome composition to improve the state of the cardiovascular condition.