Method and system for microbiome-derived characterization, diagnostics and therapeutics for cutaneous conditions

A method for diagnosing and treating a cutaneous condition of a subject, the method comprising:

• providing sampling kits to a population of subjects, each sampling kit including a sample container having a pre-process reagent component;
• receiving an aggregate set of samples from the sampling kits of the population of subjects;
• with amplification substrates including identifying one or more of:
• condition-specific primers, targeted enriched substrates, and direct sequencing of substrates of a next generation sequencing platform of a sample processing system, generating sequence datasets upon sequencing nucleic acid content of microorganism portions of the aggregate set of samples;
• generating a microbiome feature dataset, including diversity features, for the population of subjects based upon the sequence datasets for the population of subjects;
• generating a characterization model of the cutaneous condition from features extracted from the microbiome feature dataset and a supplementary dataset informative of characteristics associated with the cutaneous condition;
• characterizing a subject with the cutaneous condition upon processing a sample from the subject according to the characterization model;
• and
• providing a therapy to the subject with the cutaneous condition.