Pulmonary intravascular non-classical monocytes mediate lung transplant ischemia-reperfusion injury
AssigneeNorthwestern University
InventorsAnkit Bharat, G.R. Scott Budinger
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Abstract
Disclosed are methods and compositions which may be utilized to inhibit and/or deplete non-classical monocytes during a transplantation procedure. The disclosed methods and compositions may be utilized in order to reduce damage to organs and tissues during a transplantation procedure and/or to improve the success rate of the transplantation procedure.
Claims20
A method comprising treating a donor prior to harvesting an allograft from the donor with a pharmaceutical agent that inhibits the activity of non-classical monocytes.
A method comprising treating an allograft prior to transplantation with an agent that inhibits the activity of non-classical monocytes and/or an agent that depletes the allograft of non-classical monocytes.
A method for preserving an allograft after harvest, the method comprising storing the allograft in a preservation solution comprising an agent inhibits the activity of non-classical monocytes and/or a chelator of divalent cations.
A composition comprising:
- (a) a harvested allograft;
- and
- (b) at least one of (i) an agent inhibits the activity of non-classical monocytes;
- and (ii) a chelator of divalent cations.
Dependencies are inferred from the claim text.