Arenaviruses for use in the treatment and/or prevention of tumors and method for producing arenaviruses with (improved) tumor-regression properties.
OwnerKarl Sebastian Lang, Halime Kalkavaninventors
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Abstract
The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.
Claims18
1-17. (canceled)
An arenavirus for use in the treatment and/or prevention of a tumor, wherein the arenavirus is free of genomic foreign RNA.
The arenavirus of 22, wherein the carcinoma is selected from the group comprising or consisting of anal carcinoma, bronchial carcinoma, lung carcinoma, endometrial carcinoma, gallbladder carcinoma, hepatocellular carcinoma, testicular carcinoma, colorectal carcinoma, laryngeal carcinoma, oesophogeal cancer, gastric carcinoma, breast carcinoma, renal carcinoma, ovarian carcinoma, pancreas tumor, pharyngeal carcinoma, prostate carcinoma, thyroid carcinoma, melanoma and cervical carcinoma.
A medicament for use in the treatment and/or prevention of a tumor, wherein the medicament comprises an arenavirus and preferably a pharmaceutically acceptable carrier.
An in vitro method for preparing an arenavirus with tumor-regressive or improved tumor-regressive properties, the method comprising the following steps:
- a) infecting dendritic cells or tumor cells with an arenavirus,
- b) culturing the arenavirus in the infected den-dritic cells or infected tumor cells and;
- c) isolating the cultured arenavirus or a subset of the cultured arenavirus from the infected dendritic cells or infected tumor cells.
Dependencies are inferred from the claim text.