Novel industrial crystallization method of cefuroxime sodium and preparation thereof
AssigneesHainan Lingkang Pharmaceutical Co., Ltd, Tianjin University
InventorsLinggang TAO, Hongxun HAO, Jingkang WANG
Life of this patent
Estimating the term…
Abstract
It discloses a new industrial crystallization method of Cefuroxime Sodium, wherein supercritical fluid extraction technology and traditional crystalline technology are combined to realize the recrystallization of Cefuroxime Sodium. Processes such as extraction, adsorption, crystallization and drying are carried out with a supercritical fluid, a solvent, an extraction cell and a crystallization tank to realize the recrystallization of Cefuroxime Sodium under a specific pressure at a specific temperature.
Claims7
A novel industrial crystallization method of Cefuroxime Sodium, characterized in that, combining supercritical fluid extraction and traditional crystallization to realize the recrystallization of Cefuroxime Sodium, preferably dissolving Cefuroxime Sodium in an organic solvent, extracting the organic solvent and the solute in the solution of Cefuroxime Sodium by a supercritical fluid, and changing the solubility of the ingredients in the organic solvent and the supercritical fluid by adjusting the temperature and the pressure to make Cefuroxime Sodium crystallize.
Dependencies are inferred from the claim text.