A modified microorganism for the optimized production of 2,4-dihydroxybutyrate with enhanced 2,4-dihydroxybutyrate efflux
AssigneeMetabolic Explorer
InventorsWanda DISCHERT, Laurence DUMON-SEIGNOVERT, Perrine VASSEUR, Gwénaëlle BESTEL-CORRE, Philippe SOUCAILLE
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Abstract
The present invention relates to a recombinant microorganism capable of producing 2,4-dihydroxybutyrate, which is characterized by an increased cellular export, and preferably by a decreased cellular import, of said 2,4 DHB. The invention also relates to a method for the optimized productionof 2,4-dihydroxybutyrate by culturing said microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
Claims12
A microorganism genetically modified for producing 2,4-dihydroxybutyrate by fermentation, wherein said microorganism is further genetically modified for reducing intracellular 2,4-dihydroxybutyrate accumulation, thereby optimizing 2,4-dihydroxybutyrate production.
Dependencies are inferred from the claim text.