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US 2018/0105802 A1Published application
Viral Targeting with Knottins
OwnerCorey Raffel, Sangeet Lalinventors
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Abstract
The use of targeting knottin polypeptides provides a means of selectively infecting target cells presenting species bound by the knottins. The targeted viruses may be used as cytotoxic agents, for example, as oncolytic viral therapeutics. Alternatively, the knottin-targeted viruses may be used to transform target cells in a gene therapy or immunotherapy context. An effective retargeted measles virus directed to integrins is demonstrated.
Claims20
An engineered virus comprising,
- one or more knottin polypeptides, wherein the one or more knottin polypeptides is configured such that it confers selective infection of a target cell type by the virus,
- wherein the target cell type expresses one or more target binding moieties that is selectively bound by the one or more knottins.
A method of selectively infecting a target cell, comprising
- administering an engineered virus to the target cell wherein the engineered virus comprises one or more knottin polypeptides which selectively bind to one or more target binding moieties present on the target cell.
Dependencies are inferred from the claim text.