Treatment of cancer using recall antigens delivered by attenuated bacteria
AssigneeAlbert Einstein College of Medicine
InventorClaudia Gravekamp
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Abstract
Methods, pharmaceutical compositions and vaccines comprising an attenuated bacteria that expresses a recall antigen are disclosed for treatment of cancer.
Claims26
A method of treating a tumor in a subject, and/or reducing or preventing metastasis of a tumor in a subject, comprising administering to the subject an attenuated bacteria that expresses a recall antigen in an amount effective to treat the tumor, and/or to reduce or prevent metastasis of the tumor.
A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an attenuated bacteria that expresses a recall antigen.
A cancer vaccine comprising an attenuated bacteria that expresses a recall antigen.
The cancer vaccine of claim 25, wherein the bacteria is one of more of Listeria monocytogenes, Salmonella thyphimurium, Vibrio cholera, Clostridium, and Bifidobacterium breve.
Dependencies are inferred from the claim text.