Modified microorganism for the optimized production of 2,4-dihydroxybutyrate
AssigneeMetabolic Explorer
InventorsPhilippe SOUCAILLE, Gwénaëlle BESTEL-CORRE, Laurence DUMON-SEIGNOVERT
Life of this patent
Estimating the term…
Abstract
The present invention relates to a genetically modified microorganism for the production of 2,4-dihydroxybutyrate, by metabolic transformation of xylose via the 1,2,4-butanetriol intermediate. The invention also relates to a method for the production of 2,4-dihydroxybutyrate by culturing said genetically modified microorganism in a fermentation medium and recovering 2,4-DHB from said medium.
Claims17
A microorganism genetically modified for the production of 2,4-dihydroxybutyrate by converting xylose into 1,2,4-butanetriol, wherein said microorganism is further genetically modified for:
- i) oxidizing 1,2,4-butanetriol into 2,4-dihydroxybutanal;
- and
- ii) oxidizing 2,4-dihydroxybutanal into 2,4-dihydroxybutyrate.
Dependencies are inferred from the claim text.