Treatment of eosinophilic inflammatory disease
AssigneeNorthwestern University
InventorsRobert C. Kern, Jin-Young Min, Robert P. Schleimer, Bruce K. Tan
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Abstract
Provided herein are compositions and methods for the treatment of eosinophilic inflammatory diseases of the mucosal surfaces using proton pump inhibitors. In particular, administration of inhibitors of H,K-ATPase (ATP12A) provides treatment for eosinophilic inflammatory diseases.
Claims16
A method of treating or ameliorating the symptoms of an eosinophilic inflammatory disease in a subject comprising inhibiting ATP12A expression and/or activity with the subject.
A pharmaceutical composition comprising (a) an inhibitor of ATP12A expression and/or activity, (b) an additional agent for treating or ameliorating the symptoms of an eosinophilic inflammatory disease, and (c) a pharmaceutically-acceptable carrier.
Dependencies are inferred from the claim text.