Therapeutic compounds and formulations for intranasal delivery
AssigneeRegents of the University of Minnesota
InventorsRonald A. Siegel, Mamta Kapoor, Narsihmulu Cheryala, Gunda I. Georg, James C. Cloyd
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Abstract
Certain embodiments of the invention provide a formulation suitable for nasal administration comprising water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, as well as methods of use thereof.
Claims26
A formulation suitable for nasal administration comprising:
- water, a prodrug of a therapeutic agent, and an enzyme that is suitable for intranasal conversion of the prodrug to the therapeutic agent, wherein the therapeutic agent is midazolam or a precursor of midazolam.
A kit comprising a) a prodrug of a therapeutic agent in an aqueous solution;
- b) an enzyme;
- and c) instructions for concurrent intranasal administration of the prodrug and the enzyme, wherein the therapeutic agent is midazolam or a precursor of midazolam.
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17-18. (canceled)
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A compound of formula:
- or a salt thereof.
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24-31. (canceled)
A formulation suitable for nasal administration comprising:
- water and a prodrug of a therapeutic agent that is suitable for enzymatic intranasal conversion to the corresponding therapeutic agent, wherein the therapeutic agent is midazolam or a precursor of midazolam.
34-37. (canceled)
Dependencies are inferred from the claim text.