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US 2018/0079711 A1Published application
Glaucocalyxin a derivative and preparation method and application thereof
AssigneeSuzhou Pharmavan Cancer Research Center Co., Ltd.
InventorsHaimei Feng, Rensen Zhou, Xiang Chen, Yunhui Yu, Qian Liu, Yong Li, Shiping Deng, Chuangliang Jiang
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Abstract
Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e.g. difficult-to-treat diseases such as systemic lupus erythematosus, psoriasis and triple-negative breast cancer
Claims21
Glaucocalyxin A derivative represented by formula (I):
- wherein R is any one selected from the group consisting of dimethylamino, diethylamino, piperidine-1-yl, piperazine-1-yl, hexamethyleneiminyl, morpholine-1-yl, N-phenyl-N-(3-oxocyclohexanyl)amino, N-p-chlorophenyl-N-(2-oxo-butanyl)amino, N-2-chlorophenyl-N-(2-oxo-butanyl)amino, benzylamino, purinyl-9-yl, 2-amino-6-hydroxypurine-9-yl, 4-methylpiperazine-1-yl, N-phenyl-N-methyl-amino, dibenzyl-amino, imidazole-1-yl, 2-methyl imidazole-1-yl, N-phenyl-N-(3-oxo-butanyl)amino, pyrrole-1-yl, 2-hydroxyacylpyrrole-1-yl, 2-methylpyrrolidine-1-yl, 3-methylpyrrole-1-yl, 2-oxo-pyrrole-1-yl, 3-aminoacylphenylamino, p-aminoacylphenylamino, amino acid substitutional;
- or a salt thereof.
-10. (canceled)
Dependencies are inferred from the claim text.