Virus-like particle compositions and vaccines against epstein-barr virus infection and disease
AssigneeUniversity of Massachusetts
InventorsJavier Gordon Ogembo, Trudy Morrison
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Abstract
The present invention relates to prophylactic and/or therapeutic vaccines that contain Newcastle disease virus (NDV) virus-like particles (VLPs) comprising one or more Epstein-Barr Virus (EBV) antigens. In one embodiment, the invention provides a recombinant virus-like particle (VLP) comprising, in operable combination, a) Newcastle disease virus (NDV) matrix (M) protein, and b) one or more Epstein-Barr Virus (EBV) antigens. The invention's prophylactic and/or therapeutic vaccines are useful for preventing and/or treating infection with EBV and/or disease associated Epstein-Barr Virus, such as cancer.
Claims23
A recombinant virus-like particle (VLP) comprising, in operable combination,
- a) Newcastle disease virus (NDV) matrix (M) protein,
- b) NDV neucleocapsid (NP) protein, and
- c) one or more tumor-associated EBV antigen,
- wherein said one or more tumor-associated EBV antigen is inside said VLP.
Dependencies are inferred from the claim text.