Compositions and methods for cardiac therapy
AssigneesVentrix, Inc., The Regents of the University of California
InventorsKaren CHRISTMAN, Jennifer SINGELYN, Jessica DEQUACH, Adam KINSEY
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Abstract
Provided herein are methods and compositions for cardiac therapy. Such compositions include extracellular-matrix (ECM)-based products that can be used to support tissue repair. The compositions can be used for various purposes. In some cases, they can be introduced into a subject in order to preserve and/or repair damaged heart tissue.
Claims19
-46. (canceled)
A composition comprising digested, decellularized extracellular matrix derived from tissue, the extracellular matrix having a pore size of about 30 to 40 microns, wherein the composition is injectable through a catheter with an inner diameter of 25G or smaller, and wherein the extracellular matrix comprises glycosaminoglycan in a concentration of between about 60 to 120 μg per mL of the extracellular matrix.
A tissue culture device comprising:
- a composition comprising digested, decellularized extracellular matrix derived from tissue, the extracellular matrix having a pore size of about 30 to 40 microns;
- and a substrate, wherein the tissue culture device is used for in vitro tissue culture;
- and wherein the extracellular matrix comprises from about 10 to about 20 μg of glycosaminoglycans per mg of the extracellular matrix.
The method of claim 13, wherein said composition is injected earlier than one month following myocardial infarction.
The method of claim 13, wherein said composition degrades within three months following injection or implantation.
The composition of claim 1, wherein following injection or implantation in a subject, the composition degrades within three months.
The composition of claim 1, wherein the material transitions to gel from in vivo.
The composition of claim 1, wherein the digested, decellularized extracellular matrix derived from tissue is enzymatically digested.
Dependencies are inferred from the claim text.