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US 2018/0071408 A1Published application
Cholecystokinin 2 receptor targeted nir imaging and use thereof
AssigneeOn Target Laboratories, LLC
InventorsSumith A. Kularatne, Pravin Gagare, Mohammad Noshi
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Abstract
Compounds are described herein where CCK2R targeting ligands are attached to an imaging agent through a linker. The compounds can be used in the detection, diagnosis, imaging and treatment of cancer.
Claims47
A compound having the formula
- B-L-Z
- wherein B is a ligand selected from the group consisting of
- wherein when n is 0, m is 1 or when n is 1, m is 0,
- wherein L is a linker, and
- wherein Z is an imaging agent
- or a pharmaceutically acceptable salt thereof, or isotopes thereof.
3 more elements
A compound having the formula selected from the group consisting of
- wherein, R1 is independently selected from the group consisting of O, S, N and C,
- R2 is independently selected from the group consisting of CH2 and CH2CH2, and
- each of R3, R4, and R5 are independently selected from the group consisting of H, Na, K, and NH4,
- or a pharmaceutically acceptable salt thereof, or isotopes thereof.
1 more element
Dependencies are inferred from the claim text.