Back to results
US 2018/0064649 A1Published application
Platform drug delivery system utilizing crystal engineering and theanine dissolution
AssigneeTheaprin Pharmaceuticals Inc.
InventorsHarry G. BRITTAIN, Philip V. FELICE
Life of this patent
Estimating the term…
Abstract
A platform drug delivery system and a method of improving the delivery of low solubility pharmaceuticals utilizing crystal engineering and Theanine dissolution resulting in enhanced bioactivity, dissolution rate, and solid state stability.
Claims31
A cocrystal composition comprising:
- a quantity of a theanine enantiomer;
- and
- a quantity of a drug from a class selected from the group consisting of nucleoside analog reverse transcriptase inhibitors, non-nucleoside reverse transcriptase inhibitors, non-purine selective xanthine oxidase inhibitors, leukotriene receptor antagonists, beta-adrenergic agonists/alpha-adrenergic agonists, antihypertensive agents, loop diuretics, thiazide diuretics, atypical antipsychotic/partial dopamine agonists, non-steroidal anti-inflammatory drugs, corticosteroids, antihistamines, antineoplastic agents, antibacterial agents, antibiotics, antiviral agents, antifungal agents, antiprotozoan agents, immediate dopamine precursor agent, catechol-o-methyltransferase inhibitors, ergoline dopamine agonists, ergot derivative/dopamine D2, D3, D4, 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, α2B receptor agonists, antiparkinsonian agents, direct-acting skeletal muscle relaxants, noncompetitive N-methyl D-aspartate receptor antagonists, zinc salts of gluconic acid, serotonin-1b and serotonin-1d receptor agonists/antimigraine agents, cytomegalovirus nucleoside analog DNA polymerase inhibitors and guanosine analogue antiviral agents.
A cocrystal composition comprising:
- a quantity of a theanine enantiomer;
- and
- a quantity of a drug selected from the group consisting of lasix, aspirin, epinephrine, zinc gluconate, dantrolene sodium, levodopa, entacapone, bromocriptine, cabergoline, nilotinib, memantine, ibuprofen, efavirenz, zidovudine, metronidazole, valganciclovir, fluconazole, ampicillin, erythromycin, sulfamethoxzole, cefdinir, cefadroxil, amoxicillin, daptomycin, acyclovir, febuxostat, hydrochlorothiazide, sumatriptan, prednisone, zinc gluconate, doxorubicin, irinotecan, aripiprazole, diflunisal, zafirulkast, and fexofenadine.
A cocrystal composition comprising:
- a quantity of a theanine enantiomer;
- and
- a quantity of a drug for treating a condition selected from the group consisting of acute pulmonary edema/congestive heart failure;
- acute myocardial infarction;
- acute ischemic stroke;
- acute allergic reactions, anaphylactic reactions from medication, food, latex, insect bites/stings, cardiac arrest, acute exacerbation of asthma, ventricular fibrillation, airway obstruction;
- Australian box jelly fish envenomations;
- neurologic emergencies;
- diseases/conditions associated with excessive amounts of glutamate;
- Parkinson's disease;
- hyperprolactinemia including amenorrhea with or without galactorrhea, infertility or hypogonadism, prolactin-secreting adenomas, acromegaly, post encephalitic Parkinson's disease;
- hyperprolactinemic disorders, either idiopathic or due to pituitary adenomas;
- Imatinib resistant chronic myelogenous leukemia, Alzheimer's disease, Huntington's disease, dementia, amyotrophic lateral sclerosis;
- neurodegenerative diseases/conditions;
- acute renal colic;
- acute pericarditis;
- ligament injury;
- HIV/AIDS;
- clostridium difficile, trichomoniasis, bacterial infections of the vagina, acne rosacea, giardiasis, amoebiasis, abscess, surgical wound infections, helicobacter infections, pseudomembranous enterocolitis, bacteroides infections;
- cytomegalovirus retinitis in AIDS patients, AIDS associated opportunistic infections, CMV disease in patients who have received an organ transplant;
- herpes simplex encephalitis, herpes labialis, genital herpes, varicella-zoster, acute mucocutaneous HSV infections in immunocompromised patients, acute chickenpox in immunocompromised patients, ophthalmic herpes, herpes simplex blepharitis;
- oral candida/fungal infection;
- listeriosis;
- bronchitis, diphtheria, legionnaires disease, pertussis pneumonia, dental prophylaxis;
- uncomplicated urinary tract infections, pneumocystis carinii pneumonia, toxoplasmosis, shigellosis, traveler's diarrhea;
- community-acquired pneumonia, acute exacerbations of chronic bronchitis, acute maxillary sinusitis, pharyngitis, tonsillitis, uncomplicated skin and soft tissue infections, acute bacterial otitis media;
- impetigo/soft tissue infections;
- pharyngitis, tonsillitis, uncomplicated skin infections, uncomplicated soft tissue infections, lower respiratory infections, early stage Lyme disease;
- staphylococcus aureus bacteremia including right sided endocarditis, complicated skin and skin structure gram-positive bacterial infections including MRSA;
- gout/hyperuricemia;
- heart failure, hypertension, pulmonary edema, fluid retention associate with ascites, liver cirrhosis, nephrotic syndrome;
- hypertension, heart failure, diabetes insipidus, fluid retention in patients with congestive heart failure, cirrhosis of the liver, nephrotic syndrome in patients taking steroids, nephrotic syndrome in patients taking estrogen;
- migraine, cluster headaches;
- Ramsay Hunt Syndrome;
- inflammation, autoimmune disease, Bell's palsy, Hashimoto's encephalopathy, skin disease, mild to moderate allergies, asthma, COPD, chronic inflammatory demyelinating polyneuropathy, rheumatic disorders, allergic reactions, ulcerative colitis, Crohn's disease, adrenocortical insufficiency, thyroiditis, laryngitis, sinusitis, mild to moderate urticaria, recurrent pericarditis, multiple sclerosis, nephrotic syndrome, myasthenia gravis, poison oak exposure, acute lymphoblastic leukemia, Non-Hodgkin lymphoma, hodgkin's lymphoma, multiple myeloma and other hormone-sensitive tumors, uveitis, sarcoidosis;
- rhinovirus colds;
- acute lymphoblastic leukemia, acute myelobastic leukemia, Wilm's tumor, neuroblastoma, soft tissue and bone sarcomas, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin's disease, malignant lymphoma, small cell histologic type bronchogenic carcinoma, axillary lymph node involvement following resection of primary breast cancer;
- metastatic carcinoma of the colon and rectum;
- dopamine-responsive dystonias;
- schizophrenia, bipolar disorder, autism;
- pain;
- asthma;
- hay fever;
- and stabilization of bimembrane structures.
41 more elements
A cocrystal composition comprising:
- a quantity of L-theanine;
- and a quantity of a chemical composition selected from the group consisting of acyclovir, amoxicillin, ampicillin, aripiprazole, bromocriptine, cabergoline, cefadroxil, cefdinir, dantrolene, daptomycin, diflunisal, doxorubicin, efavirenz, entacapone, epinephrine, erythromycin, febuxostat, fexofenadine, fluconazole, furosemide, hydrochlorothiazide, (R)-ibuprofen, irinotecan, levodopa, memantine, metronidazole, nilotinib, prednisone, sulfamethoxazole, sumatriptan, valganciclovir, zafirlukast, zidovudine, and gluconate-zinc.
A method of improving a physical property of an active pharmaceutical ingredient, comprising the step of combining the active pharmaceutical ingredient with a quantity of L-theanine, wherein the physical property is selected from the group consisting of solubility, stability, and dissolution rate.
Dependencies are inferred from the claim text.