Vaccine, therapeutic composition and methods for treating or inhibiting cancer
AssigneeUniversity of Iowa Research Foundation
InventorGail Bishop
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Abstract
The present invention provides a method of preparing an anti-cancer composition comprising activated immune cells and a pharmaceutically acceptable excipient. The present invention further provides a method of contacting immune cells obtained from an animal with an optimal combination of activating agents and with an immunogenic material to form the activated immune cells.
Claims58
A method of preparing an anti-cancer composition comprising activated immune cells and a pharmaceutically acceptable excipient, the method comprising contacting immune cells obtained from an animal with an activating agent and with an immunogenic material obtained from the animal to form the activated cells, wherein the activated immune cells are a population of cells that are at least 90% B-lymphocytes.
A method of preparing an anti-cancer composition comprising activated cells and a pharmaceutically acceptable excipient, the method comprising:
- obtaining immune cells from an animal,
- obtaining immunogenic material from the animal,
- contacting the cells with an activating agent, and
- contacting the cells with the immunogenic material to generate the activated cells,
- wherein the activated immune cells are a population of cells that are at least 90% B-lymphocytes.
A pharmaceutical composition comprising a pharmaceutically acceptable excipient and immune cells obtained from an animal, wherein the cells have been stimulated ex vivo with an activating agent and have been stimulated ex vivo with an immunogenic material obtained from the animal for the therapeutic treatment of cancer, wherein the activated immune cells are a population of cells that are at least 90% B-lymphocytes.
Dependencies are inferred from the claim text.