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US 2018/0044644 A1Published application
PIV5-Based Amplifying Virus-Like Particles
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorBiao He
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Abstract
Compositions, methods of use and methods of manufacture are provided for PIV5-based amplifying VLP (AVLP) that can deliver an expressible heterologous nucleotide sequence in target cells without producing progeny, and which demonstrate useful safety and therapeutic efficacy in multiple animal and human health applications, such as vaccination, gene therapy and cancer therapy.
Claims26
An isolated polynucleotide which comprises:
- (i) at least a portion of each of PIV5 NP, V/P and L genes, and
- (ii) a heterologous non-PIV5 nucleotide sequence,
- wherein said polynucleotide lacks one or more of the PIV5 genes selected from the group consisting of M, F, SH and HN, or is incapable of expressing one or more of the PIV5 proteins selected from the group consisting of M, F, SH and HN.
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Dependencies are inferred from the claim text.