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US 2018/0044331 A1Published application
Piperazine derivatives for treating disorders
AssigneesThe University of Nottingham, NewSouth Innovations Pty Limited
InventorsDavid Bates, Jonathan Morris
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Abstract
Anti-angiogenic treatments, treatments of hyperpermeability disorders, treatments of neuropathic and neurodegenerative disorders, pain treatments, methods of reducing the risk of pre-eclampsia and compounds for use in such methods are described.
Claims20
A method of treating pain, comprising administering to a subject in need thereof a compound of Formula (I)
- or a pharmaceutically acceptable salt thereof;
- wherein:
- n=1, 2, 3 or 0;
- R1=a 4- to 8-membered carbocyclic group, which may have one or more substituent;
- a 4- to 8-membered heterocyclic group comprising one oxygen atom, which may have one or more substituent;
- a 4- to 8-membered heterocyclic group comprising one nitrogen atom, which may have one or more substituent, a 4-to 8-membered heterocyclic group comprising one nitrogen atom and one oxygen atom which may have one or more substituent;
- a 4- to 8-membered heterocyclic group comprising two nitrogen atoms which may have one or more substituent;
- a 4- to 8-membered heterocyclic group comprising three nitrogen atoms which may have one or more substituent, or a condensed aromatic heterocyclic group, which may have one or more substituent;
- X═CH, NH or N;
- Y═CH, NH or N;
- Z═O, S, N or NH;
- and
- R2═H, a C1-6 alkyl group;
- a phenyl group;
- a 4- to 8-membered heterocyclic group;
- or a condensed aromatic heterocyclic group, each of which may have one or more substituent.
13 more elements
Dependencies are inferred from the claim text.