# US 2018/0043049 A1 · Multifunctional transdermal dressing for wounds

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- Number: US 2018/0043049 A1
- Document ID: US20180043049A1
- Status: Published application
- Kind: A1
- Application number: 15/345,122
- Filed: 2016-11-07
- Published: 2018-02-15
- Earliest claimed: 2013-03-15
- Assignees: Materials Modification, Inc.
- Applicants: Materials Modification Inc.
- Inventors: KRISHNASWAMY KASTHURI RANGAN; TIRUMALAI SRINIVAS SUDARSHAN
- Web page: https://patentgrep.com/patent/US20180043049A1

## CPC

- A61L 15/18: containing inorganic materials
- A61F 13/00063: {comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00)}
- A61K 31/167: having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
- A61K 31/4468: having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
- A61K 33/38: Silver; Compounds thereof
- A61L 15/44: Medicaments
- A61L 15/46: Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
- A61F 2013/00157: {for burns or skin transplants (A61F2013/00187 takes precedence; not adhering to the wound A61F2013/00217)}
- A61L 2300/402: Anaestetics, analgesics, e.g. lidocaine
- A61L 2300/404: Biocides, antimicrobial agents, antiseptic agents
- A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K)
- A61F: FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS (dental prosthetics A61C)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic. The multifunctional polymer-free clay product provides antimicrobial and pain relieving properties. Method of treatment of burns using the multifunctional polymer-free clay product having antimicrobial and pain relieving properties. Methods of preparing multifunctional polymer-free clay products having a clay, a zwitterion, a silver compound, and, an analgesic.

## Claims

### Claim 1

A multifunctional polymer-free clay product comprising a clay, a zwitterion, an antimicrobial agent, and, an analgesic, and wherein the multifunctional polymer-free clay product provides antimicrobial and pain relieving properties.

### Claim 2 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the clay is selected from the group consisting of montmorillonite, kaolinite, smectite, and bentonite.

### Claim 3 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the antimicrobial agent is selected from the group consisting of silver ion, copper, silver-containing compounds, and, copper containing compounds.

### Claim 4 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the zwitterion is selected from the group consisting of betaine, betaine hydrochloride, choline chloride, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium chloride, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium bromide, 3-Benzyl-5-hydroxymethyl)-4-methylthiazolium fluoride, [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide, [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium chloride and 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium iodide.

### Claim 5 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the analgesic is selected from the group consisting of opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs) and adjuvant analgesics, capsaicin, clonidine, ketamine, Morphine, fentanyl, Buprenorphine, fentanyl base, lidocaine base, loperamide base, cannabinoids, and combinations thereof.

### Claim 6 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein a thickness of the multifunctional polymer-free clay product ranges from about 1 micrometer to about 500 micrometer.

### Claim 7 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein a thickness of the multifunctional polymer-free clay product ranges from about 1 micrometer to about 100 micrometers.

### Claim 8 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the polymer-free clay product achieves a bending radius of curvature ranging from about 0.4 millimeter to about 10 centimeters.

### Claim 9 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the polymer-free clay product has greater than 50 percent absorption of visible light.

### Claim 10 (depends on 1)

The multifunctional polymer-free clay product of claim 1, wherein the polymer-free clay product does not incorporate a polymer.

### Claim 11 (depends on 1)

A multifunctional dressing comprising the multifunctional polymer-free clay product of claim 1.

### Claim 12 (depends on 1)

A method of treating burns comprising administering the multifunctional polymer-free clay product of claim 1.

### Claim 13

A method of preparing a multifunctional polymer-free clay product comprising an antimicrobial agent and an analgesic, the method comprising:
a) mixing a clay, the antimicrobial agent and water to form a first slurry;
b) washing the slurry of step a) with water to obtain a washed second slurry;
c) adding a zwitterion and water to the washed second slurry of step b) to obtain a third clay slurry;
d) casting the third clay slurry of step c) onto a substrate to obtain a first dried product;
e) adding drops of the analgesic in a non-aqueous solvent onto the first dried product of step d) to obtain a resultant product,
f) drying the resultant product to obtain a second dried product;
g) separating the second dried product of step f) from the substrate of step d);
wherein the second dried product of steps f) and g) is the multifunctional polymer-free clay product which provides both antimicrobial and pain relieving properties, and wherein the antimicrobial agent in the multifunctional polymer-free clay product is selected from the group consisting of silver ion, copper, silver-containing compounds, and, copper containing compounds.

### Claim 14 (depends on 13)

The method of claim 13, wherein the silver-containing compound is silver nitrate.

### Claim 15 (depends on 13)

The method of claim 13, wherein the analgesic is selected from the group consisting of fentanyl base, lidocaine base, loperamide base, and combinations thereof.

### Claim 16 (depends on 13)

The method of claim 13, wherein the substrate is selected from the group consisting of a silicone sheet, a fabric, and a glass surface.

### Claim 17 (depends on 13)

The method of claim 13, wherein the clay is selected from the group consisting of montmorillonite, kaolinite, smectite, and bentonite.

### Claim 18 (depends on 13)

The method of claim 13, wherein the zwitterion is selected from the group consisting of betaine, betaine hydrochloride, choline chloride, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium chloride, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium bromide, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium fluoride and 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium iodide.

### Claim 19 (depends on 13)

A multifunctional polymer-free clay product prepared by the method of claim 13.

### Claim 20

A method of preparing a multifunctional polymer-free organo modified clay product comprising an antimicrobial agent and an analgesic, the method comprising:
a) mixing a clay, the antimicrobial agent and water to form a first slurry;
b) washing the first slurry of step a) with water to obtain a washed second slurry;
c) adding a mixture of water and non-aqueous solvent containing betaine and an analgesic to the washed second slurry of step b) to obtain a third clay slurry;
d) casting the third clay slurry of step c) onto a substrate to obtain a dried product;
e) separating the dried product of step d) from the substrate to obtain a separated dried product, wherein the separated dried product is the multifunctional polymer-free clay product, wherein the multifunctional polymer-free clay product provides antimicrobial and pain relieving properties, and wherein the antimicrobial agent is selected from the group consisting of silver ion, copper, silver-containing compounds, and, copper containing compounds.

### Claim 21 (depends on 20)

The method of claim 20, wherein the silver compound is silver nitrate.

### Claim 22 (depends on 20)

The method of claim 20, wherein the analgesic is selected from the group consisting of fentanyl base, lidocaine base, loperamide base, and combinations thereof.

### Claim 23 (depends on 20)

The method of claim 20, wherein the substrate is selected from the group consisting of a silicone sheet, a fabric, and a glass surface.

### Claim 24 (depends on 20)

The method of claim 20, wherein the clay is selected from the group consisting of montmorillonite, kaolinite, smectite, and bentonite.

### Claim 25 (depends on 20)

The method of claim 20, wherein the zwitterion is selected from the group consisting of betaine, betaine hydrochloride, choline chloride, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium chloride, 3-Benzyl-5-2-hydroxymethyl)-4-methylthiazolium bromide, 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium fluoride, [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide, [2-(Methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium chloride and 3-Benzyl-5-(2-hydroxymethyl)-4-methylthiazolium iodide.

### Claim 26 (depends on 20)

A multifunctional polymer-free clay product prepared by the method of claim 20.

### Claim 27

A multifunctional antimicrobial and analgesic dressing comprising a backing film and a multifunctional polymer-free clay product, wherein the multifunctional polymer-free clay product comprises a clay, a zwitterion, an antimicrobial agent, and, an analgesic, whereby the multifunctional polymer-free clay product provides antimicrobial and pain relieving properties, and the backing film is a polymeric film impermeable to liquid water.

### Claim 28 (depends on 27)

The multifunctional antimicrobial and analgesic dressing of claim 27 further comprising a diffusion control membrane, wherein the diffusion control membrane provides controlled release of the analgesic in the multifunctional polymer-free clay product.

### Claim 29

A multifunctional antimicrobial and analgesic dressing comprising a backing film and more than one multifunctional polymer-free clay product, wherein each of the multifunctional clay product in the more than one multifunctional polymer-free clay product comprises a clay, a zwitterion, an antimicrobial agent, and, an analgesic,
wherein the multifunctional antimicrobial and analgesic dressing provides antimicrobial and pain relieving properties, wherein the backing film is a polymeric film impermeable to liquid water.

### Claim 30 (depends on 29)

The multifunctional antimicrobial and analgesic dressing of claim 29, further comprising a diffusion control membrane, wherein the diffusion control membrane provides controlled release of the analgesic from the multifunctional polymer-like clay product.