Targeted, metal-catalyzed fluorination of complex compounds with fluoride ion via decarboxylation
AssigneeThe Trustees of Princeton University
InventorsJohn T. Groves, Xiongyi Huang
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Abstract
Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
Claims30
A method of targeted fluorination comprising combining a mono-fluoro-aryl iodine-(III) carboxylate and a manganese catalyst.
A method of targeted fluorination of a compound containing a carboxyl group, the method comprising combining the compound, a nucleophilic fluoride source, a manganese catalyst, a solvent and an iodine(III) oxidant.
A composition comprising a fluorinated product that includes at least one compound selected from the group consisting of:
A method of direct radioactive labeling of a compound containing a carboxyl group, the method comprising combining the compound, a nucleophilic, radioactive fluoride source, a manganese catalyst, a solvent and an iodine (III) oxidant.
A composition comprising a radio-labeled compound selected from the group consisting of:
- wherein the F in compounds 1-28 is 18F.
Dependencies are inferred from the claim text.