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US 2018/0028675 A1Published application
Rvg derived peptides
AssigneeUnited Arab Emirates University
InventorOmar M. Ali El-Agnaf
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Abstract
The invention relates to short RVG derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides.
Claims27
A peptide comprising the structure:
- A1-B-C or C-B-A2, wherein B is optionally present or absent;
- and wherein
- A1 comprises the sequence CDIFTNSRGK (SEQ ID NO:2) or a variant or derivative thereof;
- A2 comprises the sequence kGrsntfidc (SEQ ID NO:3) or a variant or derivative thereof;
- B is a linker sequence;
- and
- C is a cell penetrating peptide (CPP) sequence.
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Dependencies are inferred from the claim text.