# US 2018/0024155 A1 · Diagnostic chip

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- Number: US 2018/0024155 A1
- Document ID: US20180024155A1
- Status: Published application
- Kind: A1
- Application number: 15/546,867
- Filed: 2015-01-30
- Published: 2018-01-25
- Earliest claimed: 2015-01-30
- Assignees: Hewlett-Packard Development Company, L.P.
- Applicants: Hewlett-Packard Development Company, L.P.
- Inventors: Nicholas Matthew Cooper McGuinness; Chantelle Elizabeth Domingue; Manish Giri; Ed Friesen
- Web page: https://patentgrep.com/patent/US20180024155A1

## CPC

- G01N 35/08: using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
- B01L 3/502715: {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces}
- B01L 2200/026: Fluid interfacing between devices or objects, e.g. connectors, inlet details
- B01L 2200/04: Exchange or ejection of cartridges, containers or reservoirs
- B01L 2200/10: Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
- B01L 2200/141: Preventing contamination, tampering
- B01L 2200/16: Reagents, handling or storing thereof
- B01L 2300/023: Sending and receiving of information, e.g. using Bluetooth®
- B01L 2300/024: Storing results with means integrated into the container
- B01L 2300/0627: Sensor or part of a sensor is integrated
- B01L 2300/0663: Whole sensors
- B01L 2300/0861: Configuration of multiple channels and/or chambers in a single devices
- B01L 2300/0867: Multiple inlets and one sample wells, e.g. mixing, dilution
- B01L 2400/0406: capillary forces
- B01L 2400/0442: thermal energy, e.g. vaporisation, bubble jet
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE

## Abstract

A microfluidic diagnostic chip may comprise a substrate, a plurality of fluidic slots extending through the substrate, a plurality of microfluidic channels each coupled to a respective one of the plurality of fluidic slots to receive a plurality of fluids from the plurality of fluidic slots, and a mixing region in fluid communication with the plurality of fluidic slots to receive the plurality of fluids such that the plurality of fluids are to mix. A diagnostic chip may comprise a number of fluid slots defined through a substrate and a plurality of microfluidic channels coupled to the fluid slots to receive from the fluid slots a plurality of different fluids wherein the microfluidic channels combine and mix the plurality of different fluids.

## Claims

### Claim 1

A microfluidic diagnostic chip, comprising:
a substrate;
a plurality of fluidic slots extending through the substrate;
a plurality of microfluidic channels each coupled to a respective one of the plurality of fluidic slots to receive a plurality of fluids from the plurality of fluidic slots; and
a mixing region in fluid communication with the plurality of fluidic slots to receive the plurality of fluids such that the plurality of fluids are to mix.

### Claim 2 (depends on 1)

The microfluidic diagnostic chip of claim 1, wherein each of the plurality of microfluidic channels comprise at least one micropump.

### Claim 3 (depends on 2)

The microfluidic diagnostic chip of claim 2, wherein the micropumps cooperate to cause the plurality of fluids to pass through the respective microfluidic channels to mix the plurality of fluids to produce a specified composition of the plurality of fluids.

### Claim 4 (depends on 3)

The microfluidic diagnostic chip of claim 3, wherein a number of the plurality of microfluidic channels comprise a number of sensors to detect properties of the fluids.

### Claim 5 (depends on 4)

The microfluidic diagnostic chip of claim 4, wherein the number of sensors are to detect the properties of the fluids before mixing.

### Claim 6 (depends on 4)

The microfluidic diagnostic chip of claim 4, wherein the number of sensors are to detect the properties of the fluids after mixing.

### Claim 7 (depends on 4)

The microfluidic diagnostic chip of claim 4, wherein the number of sensors are to detect impedance values of the fluids.

### Claim 8

A diagnostic chip, comprising:
a number of fluid slots defined through a substrate; and
a plurality of microfluidic channels each coupled to a respective one of the fluid slots to receive from the fluid slots a plurality of different fluids;
wherein the microfluidic channels are to combine the plurality of different fluids in a combining region.

### Claim 9 (depends on 8)

The diagnostic chip of claim 8, wherein each of the plurality of microfluidic channels comprise at least one rnicropump.

### Claim 10 (depends on 9)

The diagnostic chip of claim 9, wherein the micropumps cooperate to combine the plurality of fluids to produce a specified composition of the plurality of fluids.

### Claim 11 (depends on 8)

The diagnostic chip of claim 8, wherein a number of the plurality of microfluidic channels comprise a number of sensors to detect properties of the fluids.

### Claim 12 (depends on 8)

The diagnostic chip of claim 8, wherein the microfluidic channels are fluidly coupled to an uppermost level of the fluid slots defined in the substrate.

### Claim 13 (depends on 11)

The diagnostic chip of claim 11, wherein each sensor is electrically coupled to an electrode for coupling the diagnostic chip to a computing device.

### Claim 14

A method of forming a microfluidic diagnostic chip, comprising:
forming a plurality of distinct fluid slots through a substrate;
forming a plurality of microfluidic channels each fluidly coupled at their respective first ends to a respective one of the plurality of fluid slots and joining at their respective second ends in a mixing region; and
forming a number of sensors within a number of the plurality of the microfluidic channels.

### Claim 15 (depends on 14)

The method of claim 14, further comprising forming a number of microfluidic pumps within a number of the plurality of microfluidic channels.