# US 2018/0024088 A1 · Improved magnesium ion selective membranes

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- Number: US 2018/0024088 A1
- Document ID: US20180024088A1
- Status: Published application
- Kind: A1
- Application number: 15/547,951
- Filed: 2016-02-01
- Published: 2018-01-25
- Earliest claimed: 2015-02-03
- Assignees: Siemens Healthcare Diagnostics Inc.
- Applicants: Siemens Healthcare Diagnostics Inc.
- Inventors: John Benco; Robert Bergquist
- Web page: https://patentgrep.com/patent/US20180024088A1

## CPC

- G01N 27/3335: {the membrane containing at least one organic component (G01N27/3271 takes precedence; aspects concerning the enzyme reagent in enzyme electrodes C12Q1/001)}
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

The present invention is directed to membranes, sensors, systems and process for the detection of magnesium ions in protein-containing samples. The novel membranes, sensors, systems, and processes are based upon the discovery that the lipophilcity of the plasticizer (or blend of plasticizers) utilized in the formulation of magnesium ion selective membranes for clinical use is inversely proportional to the sensitivity of the plasticizer(s) and directly proportional to the use life thereof.

## Claims

### Claim 1

A magnesium ion selective membrane comprising:
a polymer material;
a magnesium-selective material; and
a plasticizer comprising a measured log P value of greater than about 5.8 and less than about 12.8.

### Claim 2 (depends on 1)

The membrane of claim 1, wherein the polymer material comprises a member selected from the group consisting of polyvinyl chloride, polystyrene, polyacrylate, polycarbonate, polyester, polyamide, polyurethane, polyvinyl material, vinyl acetates, and co-polymers of any of the above.

### Claim 3 (depends on 1)

The membrane in claim 1, wherein the plasticizer comprises a blend of two or more plasticizers.

### Claim 4 (depends on 1)

The membrane in claim 1, wherein the plasticizer comprises a measured log P value of about 7 to about 9.

### Claim 5 (depends on 4)

The membrane of claim 4, wherein the plasticizer comprises a measured log P value of about 8.

### Claim 6 (depends on 1)

The membrane of claim 1, wherein the magnesium-selective material comprises an ion exchange material.

### Claim 7 (depends on 6)

The membrane of claim 6, wherein the ion exchange material comprises potassium tetrakis(4-chlorophenyl)borate.

### Claim 8 (depends on 1)

The membrane in claim 1, wherein the magnesium-selective material comprises an ionophore.

### Claim 9 (depends on 8)

The membrane of claim 8, wherein the ionophore comprises a triamide compound.

### Claim 10 (depends on 1)

A magnesium ion selective electrode comprising the membrane in claim 1.

### Claim 11 (depends on 1)

A magnesium ion selective sensor comprising a membrane in claim 1.

### Claim 12 (depends on 11)

An array of sensors comprising:
the sensor of claim 11 for determining an amount of magnesium in a protein-containing sample; and
at least one additional sensor for determining an amount of additional target analyte in the protein-containing sample.

### Claim 13 (depends on 12)

The array of claim 12, wherein the at least one additional sensor is configured for analysis of a member selected from the group consisting of pH, carbon dioxide partial pressure, oxygen partial pressure, sodium, potassium, calcium, chloride, hematocrit, hemoglobin, glucose, lactate, bilirubin, and CO-oximeter fractions.

### Claim 14

A process for analyzing a protein-based sample for magnesium comprising:
a sensor including a magnesium ion selective membrane that comprises:
a polymer material;
a magnesium-selective material; and
a plasticizer comprising a measured log P value of greater than 5.8 and less than 12.8,
introducing a protein-containing sample with the sensor; and
determining a presence of magnesium in the sample after the contacting.

### Claim 15 (depends on 14)

The process of claim 14, wherein the protein-containing sample comprises whole blood.

### Claim 16 (depends on 14)

The process in claim 14, wherein the polymer material comprises a member selected from the group consisting of polyvinyl chloride, polystyrene, polyacrylate, polycarbonate, polyester, polyamide, polyurethane, polyvinyl material, vinyl acetates, and co-polymers of any of the above.

### Claim 17 (depends on 14)

The process of claim 14, wherein the plasticizer comprises a blend of two or more plasticizers and the blend of plasticizers comprises a blend of ETH 8045 and nitro-phenyl octyl ether (NPOE).

### Claim 18 (depends on 14)

The process in claim 14, further comprising:
further comprising providing one or more additional sensors for detection of a presence of an additional analyte or property in the sample selected from the group consisting of pH, carbon dioxide partial pressure, oxygen partial pressure, sodium, potassium, calcium, chloride, hematocrit, hemoglobin, glucose, lactate, bilirubin, and CO-oximeter fractions; and
detecting the presence of the additional analyte or property in the sample.