Methods of producing four carbon molecules
AssigneeInvista North America S.A.R.L.
InventorsPaul S. Pearlman, Changlin Chen, Adriana Leonora Botes
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Abstract
Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.
Claims32
A method for biosynthesizing butadiene comprising:
- fermenting in an organism in a fermentation broth, a C4-precursor, wherein said C4-precursor comprises butanol, butanediol, or both, or derivatives thereof;
- converting C4-precursor in the fermentation broth into butenol by:
- (a) converting butanediol to butenol, or
- (b) converting butanol to butenol;
- converting the butenol into 1,3 butadiene;
- and
- optionally isolating said 1,3-butadiene.
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14-17. (canceled)
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24-35. (canceled)
A method for biosynthesising butadiene from a petrochemical feedstock comprising:
- obtaining a petrochemical feedstock comprising butane;
- fermenting butane in the presence of an organism to produce a fermentation broth comprising butene;
- and
- fermenting the butene in the presence of an organism to produce 1,3-butadiene in the fermentation broth;
- and
- optionally obtaining the 1,3-butadiene.
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A microorganism genetically modified to produce 1,3-butadiene.
A non-naturally occurring biochemical network comprising at least one substrate of FIG. 1, FIG. 2 or FIG. 3 and at least one exogenous nucleic acid encoding a polypeptide having the activity of at least one enzyme of FIG. 1, FIG. 2 or FIG. 3.
A non-naturally occurring composition, comprising at least one substrate of FIG. 1, FIG. 2 or FIG. 3, wherein said substrate is optionally bio-based, bio-derived or fermentation derived;
- at least one exogenous nucleic acid encoding a polypeptide having the activity of at least one enzyme of FIG. 1, FIG. 2 or FIG. 3;
- and at least one bio-based, bio-derived or fermentation derived product of FIG. 1, FIG. 2 or FIG. 3.
Dependencies are inferred from the claim text.