# US 2018/0023087 A1 · Screening Method For Compound Having Obesity Preventive Or Therapeutic Activity

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- Number: US 2018/0023087 A1
- Document ID: US20180023087A1
- Status: Published application
- Kind: A1
- Application number: 15/726,407
- Filed: 2017-10-06
- Published: 2018-01-25
- Earliest claimed: 2012-12-16
- Inventors: Toshihiro NAKAJIMA; Hidetoshi Fujita; Satoko Aratani; Naoko Yagishita
- Web page: https://patentgrep.com/patent/US20180023087A1

## CPC

- C12N 15/1137: {against enzymes (viral enzymes C12N15/1131; receptors C12N15/1138)}
- A61K 31/7088: Compounds having three or more nucleosides or nucleotides
- A61K 31/713: Double-stranded nucleic acids or oligonucleotides
- A61P 3/04: Anorexiants; Antiobesity agents
- C12N 15/09: Recombinant DNA-technology
- G01N 33/5023: {on expression patterns}
- C12N 2310/14: interfering nucleic acids [NA]
- G01N 2333/9015: Ligases (6)
- G01N 2800/044: Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)

## Abstract

To provide a screening method for a substance having an anti-obesity action and an anti-obesity drug. A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action. An anti-obesity drug containing, as an active ingredient thereof, an siRNA of synoviolin, a decoy nucleic acid of synoviolin, or an antisense nucleic acid of synoviolin.

## Claims

### Claim 1

A method for curing obesity of an object suffering from obesity, wherein the method comprises a step of administrating a decoy nucleic acid of synoviolin, wherein the decoy nucleic acid comprises a base sequence represented by sequence ID No. 7.

### Claim 2

A method for curing obesity of an object suffering from obesity, wherein the method comprises a step of administrating siRNA of synoviolin, wherein the siRNA comprises a base sequence selected from sequence ID Nos. 2 to 6.