# US 2018/0023030 A1 · Process for the fractionation of seeds from oleaginous plants

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- Number: US 2018/0023030 A1
- Document ID: US20180023030A1
- Status: Published application
- Kind: A1
- Application number: 15/548,218
- Filed: 2016-02-05
- Published: 2018-01-25
- Earliest claimed: 2015-02-05
- Assignees: Novamont S.p. A.
- Applicants: Novamont S.p. A.
- Inventors: Catia BASTIOLI; Giampietro BORSOTTI; Luigi CAPUZZI
- Web page: https://patentgrep.com/patent/US20180023030A1

## CPC

- C11B 1/04: of vegetable raw material {(C11B1/025 takes precedence)}
- A23K 10/37: from waste material (from hydrolysates of wood or straw A23K10/32; from molasses A23K10/33)
- A61K 8/922: {of vegetable origin}
- A61K 8/9789: Magnoliopsida [dicotyledons]
- A61K 31/7048: having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin {, digitoxin or digoxin}
- A61K 36/28: Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K 45/06: Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A61Q 19/00: Preparations for care of the skin
- C11B 1/06: by pressing
- C11B 1/08: by hot pressing
- C11B 1/10: by extracting
- C11B 13/00: Recovery of fats, fatty oils or fatty acids from waste materials
- A61K 2800/10: General cosmetic use
- A61K 2800/80: Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K 2800/805: Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
- Y02P 60/87: Re-use of by-products of food processing for fodder production
- Y02W 30/74: Recovery of fats, fatty oils, fatty acids or other fatty substances, e.g. lanolin or waxes
- C11B: PRODUCING, e.g. BY PRESSING RAW MATERIALS OR BY EXTRACTION FROM WASTE MATERIALS, REFINING OR PRESERVING FATS, FATTY SUBSTANCES, e.g. LANOLIN, FATTY OILS OR WAXES; ESSENTIAL OILS; PERFUMES (drying-oils C09F)
- A23K: FODDER
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- Y02P: CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02W: CLIMATE CHANGE MITIGATION TECHNOLOGIES RELATED TO WASTEWATER TREATMENT OR WASTE MANAGEMENT

## Abstract

The invention relates to a process for the fractionation of seeds of oleaginous plants of to the Asteraceae family, comprising at least one mechanical pressing operation of the seeds and an extraction with polar organic solvent of the first residue obtained. Said process allows to separate oil, active substances and a solid residue which is particularly suitable to be used in animal feed. The present invention also relates to said solid residue and to its use for the production of animal feed, as well as to the extracted active substances and to their use as cosmetic and/or pharmaceutical ingredient.

## Claims

### Claim 1

A process for the fractionation of seeds of oleaginous plants of the Asteraceae family in oil, solid residue and active substances comprising the steps of:
(a) subjecting said seeds to at least one mechanical pressing operation, removing at least a portion of the oil and obtaining a first residue;
(b) subjecting said first residue to extraction with a polar organic solvent and separating the remaining solid residue from the resulting liquid phase comprising oil and extracted active substances;
(c) separating the active substances and oil from said liquid phase of step b),
wherein the extraction of step b) is performed at temperatures above ambient temperature and below or equal to the boiling point of the solvent.

### Claim 2 (depends on 1)

The process according to claim 1 wherein the step (c) comprises the addition of an apolar solvent and subsequent separation of an apolar fraction comprising oil from a polar fraction comprising the active substances.

### Claim 3 (depends on 1)

The process according to claim 1 comprising, prior to step (a) at least a preliminary stage of treatment of the seeds selected from:
(i) cleaning and sieving;
(ii) decortication;
(iii) drying;
(iv) comminuting and/or grinding.

### Claim 4 (depends on 1)

The process according to claim 1, comprising a single mechanical pressing operation before the step (b).

### Claim 5 (depends on 1)

The process according to claim 1, comprising at least two operations of mechanical pressing before the step (b), at least one of which conducted at temperatures between 55-75° C.

### Claim 6 (depends on 5)

The process according to claim 5 comprising at least a step of grinding and/or drying of the intermediate solid residue between the at least two operations of mechanical pressing.

### Claim 7 (depends on 1)

The process according to claim 1, wherein said oleaginous plants of the Asteraceae family belong to the Cardueae tribe.

### Claim 8 (depends on 1)

The process according to claim 1, wherein said polar organic solvent is selected from, methanol, ethanol, isopropanol, isobutanol and higher alcohols, their esters with acetic and propionic acids, acetonitrile, acetone, methyl ethyl ketone, diethyl ketone, ethyl propyl ketone, THF, 2-methoxyethanol.

### Claim 9 (depends on 8)

The process according to claim 8 wherein said polar organic solvent is ethanol or isopropanol.

### Claim 10 (depends on 2)

The process according to claim 2, wherein said apolar solvent is selected from petroleum ether and/or hexane.

### Claim 11 (depends on 1)

A solid residue resulting from the seeds of oleaginous plants of the Asteraceae family and obtainable from step b) of the process according to claim 1, having a protein content higher than 20% by weight and an oil content of less than 10%.

### Claim 12 (depends on 11)

A method for producing animal feed which comprises adding the solid residue according to claim 11, to the animal feed.

### Claim 13 (depends on 11)

An animal feed comprising the solid residue according to claim 11, fiber, fat, minerals, carbohydrates, vitamins.

### Claim 14 (depends on 1)

An active substance obtainable from step c) of the process according to claim 1 characterized by the presence of Arctiin and Tracheloside.

### Claim 15 (depends on 14)

The active substance according to claim 14 further comprising one or more substances selected from Arctigenin, Trachelogenin, Cynarine, Cynarinine, Chlorogenic acid, Nortrachelogenin guaiayacylglyceryl ether, Silibinin, Isosilibinin, Silicristin, Silidianin, N-(p-coumaroyl)serotonin glucoside, N-feruloylserotonin glucoside, and their isomers.

### Claim 16 (depends on 14)

A composition comprising the active substance according to claim 14 as a cosmetic, dermatologic, nutraceutical and/or pharmaceutical ingredient, or as biostimulant.

### Claim 17 (depends on 2)

The process according to claim 2 comprising, prior to step (a) at least a preliminary stage of treatment of the seeds selected from:
(v) cleaning and sieving;
(vi) decortication;
(vii) drying;
(viii) comminuting and/or grinding.

### Claim 18 (depends on 2)

The process according to claim 2, comprising a single mechanical pressing operation before the step (b).

### Claim 19 (depends on 3)

The process according to claim 3, comprising a single mechanical pressing operation before the step (b).

### Claim 20 (depends on 2)

The process according to claim 2, comprising at least two operations of mechanical pressing before the step (b), at least one of which conducted at temperatures between 55-75° C.