# US 2018/0022701 A1 · 4-HETEROARYL SUBSTITUTED BENZOIC ACID COMPOUNDS AS RORgammaT INHIBITORS AND USES THEREOF

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- Number: US 2018/0022701 A1
- Document ID: US20180022701A1
- Status: Published application
- Kind: A1
- Application number: 15/647,437
- Filed: 2017-07-12
- Published: 2018-01-25
- Earliest claimed: 2012-08-15
- Assignees: Merck Sharp & Dohme Corp.
- Applicants: Merck Sharp & Dohme Corp.
- Inventors: Kenneth J. Barr; Corey E. Bienstock; John K. Maclean; Hongjun Zhang; Richard T. Beresis; Dongshan Zhang; Neville J. Anthony; Blair T. Lapointe; Yuan Tian
- Web page: https://patentgrep.com/patent/US20180022701A1

## CPC

- C07D 209/26: with an acyl radical attached to the ring nitrogen atom
- A61K 31/404: Indoles, e.g. pindolol
- A61K 31/416: condensed with carbocyclic ring systems, e.g. indazole
- A61K 31/437: the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
- A61K 31/4439: containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole (nicotine A61K31/465)
- A61K 31/5377: not condensed and containing further heterocyclic rings, e.g. timolol
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 5/14: of the thyroid hormones, e.g. T3, T4
- A61P 11/06: Antiasthmatics
- A61P 17/06: Antipsoriatics
- A61P 19/02: for joint disorders, e.g. arthritis, arthrosis
- A61P 25/00: Drugs for disorders of the nervous system
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 37/00: Drugs for immunological or allergic disorders
- A61P 37/02: Immunomodulators
- A61P 37/06: Immunosuppressants, e.g. drugs for graft rejection
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07D 231/56: Benzopyrazoles; Hydrogenated benzopyrazoles
- C07D 401/04: directly linked by a ring-member-to-ring-member bond
- C07D 401/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 403/04: directly linked by a ring-member-to-ring-member bond
- C07D 403/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 405/12: linked by a chain containing hetero atoms as chain links
- C07D 409/04: directly linked by a ring-member-to-ring-member bond
- C07D 413/04: directly linked by a ring-member-to-ring-member bond
- C07D 413/06: linked by a carbon chain containing only aliphatic carbon atoms
- C07D 417/04: directly linked by a ring-member-to-ring-member bond
- C07D 471/04: Ortho-condensed systems
- Y02A 50/30: Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- Y02A: TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE

## Abstract

The present invention relates to compounds according to Formula I (Formula I), and pharmaceutically acceptable salts or solvates thereof. Such compounds can be used in the treatment of RORgammaT-mediated diseases or conditions.

## Claims

### Claim 1

A compound according to Formula I
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Y is CH, CRa, or N;
n=0, 1, 2, 3 or 4;
A4 is CR4,
A5 is CR5,
A6 is CR6,
A7 is CR7,
Ra is (C1-4)alkyl or (C3-7)cycloalkyl;
R1 is
(i) (C3-12)carbocyclyl(C0-4)alkyl, or
(ii) a 4- to 12-membered heterocyclyl(C0-4)alkyl,
each being substituted with (i) one occurrence of R8 that is (C3-7) cycloalkyl and (ii) optionally one, two, three, or four other occurrences of R8;
R2 is hydroxycarbonyl, hydroxycarbonyl(C1-10)alkyl, (C1-10)alkylsulfoxyaminocarbonyl, or carbamoyl;
R3 is hydrogen, halogen, cyano, nitro, hydroxy, (C1-4alkylcarbonyloxy, (C1-4) alkylsulfonylamino, (C1-4) alkylcarbonylamino, (C0-4) alkylamino, (C1-4)alkyl, hydroxyl(C1-4)alkyl or (C1-4)alkoxy, wherein (C1-4)alkyl and (C1-4)alkoxy are optionally substituted with one or more halogen;
R4-R7 independently are hydrogen, halogen, amino, cyano, hydroxy, (C1-3)alkoxy, (C1-4)-alkyl, (C0-10)alkylaminocarbonyl, (C0-6)alkyoxycarbonylamino, (di)(C1-6)alkylaminocarbonyl, (C1-6)alkylcarbonylamino, (C1-4alkylamino, amino(C1-4)alkyl or —C(O)H, wherein (C1-3)alkoxy, (C1-4)alkyl, (C0-10)alkyl)aminocarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkylamino and amino(C1-4)alkyl are optionally substituted with one or more halogen, hydroxyl or (C1-3)alkoxy; or a group having the formula
optionally substituted with one or more of the following: (C1-10)alkyl, halogen, amino, cyano, hydroxy, (C1-3)alkoxy, and wherein m is 1, 2, 3, or 4; or R6 is additionally selected from:
(i) (C3-7)cycloalkyl or (C3-5)heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(ii) (C2-9)heteroaryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(iii) (C6-14)aryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(iv) (C3-5)heterocycloalkylcarbonyl or (C3-5)heterocycloalkylcarbonyl(C1-4)alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(v) (C3-5)heterocycloalkylamino, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(vi) (C3-5)cycloalkylaminocarbonyl or di(C3-5)cycloalkylaminocarbonyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(vii) (C3-5)cycloalkylcarbonylamino, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(viii) (C3-5)cycloalkyl(C1-4alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(ix) (C3-5)cycloalkylamino, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(x) (C3-5)cycloalkylcarbonyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(xi) (C2-9)heteroaryl(C1-4alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(xii) (C2-9)heteroarylcarbonyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(xiii)
(xiv) (C2-4)alkynyl, optionally substituted with one or more (C1-4)alkyl, which (C1-4)alkyl may be substituted with hydroxyl or amino; or
(xv) (C1-6)alkoxycarbonylamino,
(C1-6)alkylcarbonylamino,
(C1-6)alkylsulfonylamino(C0-4)alkyl,
(C1-6)alkylaminocarbonylamino,
(C1-6)alkoxycarbonylamino(C0-4)alkyl,
Hydroxycarbonyl(C1-4)alkylamino,
Hydroxycarbonyl,
(C1-6)alkylamino,
(C1-6)alkoxyamino,
(C0-6)alkylaminocarbonyl(C1-6)alkyl, or
di(C1-6)alkylaminocarbonyl(C1-6)alkyl,
each optionally substituted with one or more (C1-4)alkyl, hydroxyl or amino; and
R8 is halogen, cyano, amino, nitro, hydroxy, oxo(=O), H2NC(O)—, di(C1-3)alkylamino, (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl, (C3-7)cycloalkyl, (C3-5)heterocycloalkyl, (C1-4alkenyl, (C3-6)cycloalkoxy or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one, two or three halogens.

### Claim 2 (depends on 1)

The compound of claim 1 having Formula Ia
or a pharmaceutically acceptable salt or solvate thereof.

### Claim 3 (depends on 1)

The compound of claim 1 having Formula Ib
or a pharmaceutically acceptable salt or solvate thereof.

### Claim 4 (depends on 3)

The compound of claim 3, wherein Y is N.

### Claim 5 (depends on 3)

The compound of claim 3 having Formula Ic
or a pharmaceutically acceptable salt or solvate thereof.

### Claim 6 (depends on 5)

The compound of claim 5 having Formula Id
or a pharmaceutically acceptable salt or solvate thereof.

### Claim 7 (depends on 6)

The compound of claim 6, wherein Y is N.

### Claim 8 (depends on 2)

The compound of claim 2 having Formula Ie
wherein x is 1, 2, 3, 4 or 5; and at least one occurrence of R8 is (C3-7)cycloalkyl;
or a pharmaceutically acceptable salt or solvate thereof.

### Claim 9 (depends on 8)

The compound of claim 8 having Formula If
or a pharmaceutically acceptable salt or solvate thereof; wherein at least one occurrence of R8 is (C3-7)cycloalkyl.

### Claim 10 (depends on 9)

The compound of claim 9 having Formula Ig
or a pharmaceutically acceptable salt or solvate thereof; wherein at least one occurrence of R8 is (C3-7)cycloalkyl.

### Claim 11 (depends on 10)

The compound of claim 10 having Formula Ih
or a pharmaceutically acceptable salt or solvate thereof; wherein R8 is (C3-7)cycloalkyl.

### Claim 12

(canceled)

### Claim 13 (depends on 1)

The compound of claim 1, wherein Y is N.

### Claim 14 (depends on 1)

The compound of claim 1, wherein R1 is
(i) (C3-7)cycloalkyl or (C3-5)heterocycloalkyl, both being substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one, two, three, or four other occurrences of or five R8;
(ii) (C2-9)heteroaryl(C0-4)alkyl, being substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one, two, three, or four other occurrences of R8; or
(iii) (C6-14)aryl(C0-4)alkyl, being substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one, two, three, or four other occurrences of R8.

### Claim 15 (depends on 14)

The compound of claim 14, wherein R1 is (i) (C2-9)heteroaryl, or (ii) (C6-14)aryl, both substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one, two, three, or four other occurrences of R8.

### Claim 16 (depends on 15)

The compound of claim 15, wherein R1 is (C6-14)aryl substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one other occurrence of R8.

### Claim 17 (depends on 16)

The compound of claim 16, wherein R1 is phenyl substituted with (i) one occurrence of R8 that is (C3-7)cycloalkyl and (ii) optionally one other occurrence of R8.

### Claim 18 (depends on 17)

The compound of claim 17, wherein R2 is C(O)OH.

### Claim 19 (depends on 1)

The compound of claim 1, wherein R6 is

### Claim 20

A compound selected from:
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-formyl-1H-indazol-3-yl)benzoic acid;
3-fluoro-4-(1-(2-phenylpropanoyl)-1H-indazol-3-yl)benzoic acid;
3-fluoro-4-[1-(methoxyacetyl)-1H-indazol-3-yl]benzoic acid;
3-fluoro-4-[1-(pyridin-3-ylcarbonyl)-1H-indazol-3-yl]benzoic acid;
3-fluoro-4-{1-[(2-oxopyrrolidin-1-yl)acetyl]-1H-indazol-3-yl}benzoic acid;
3-fluoro-4-[1-(naphthalen-1-ylcarbonyl)-1H-indazol-3-yl]benzoic acid;
3-fluoro-4-{1-[(1-methyl-1H-indol-2-yl)carbonyl]-1H-indazol-3-yl}benzoic acid;
4-{1-[(2-bromo-3-methylphenyl)carbonyl]-1H-indazol-3-yl}-3-fluorobenzoic acid;
4-[1-(2,3-dihydro-1H-inden-4-ylcarbonyl)-1H-indazol-3-yl]-3-fluorobenzoic acid;
4-(1-{[3-(tertbutoxycarbonyl)-3-azabicyclo[3.1.0]hex-6-yl]carbonyl}-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-[1-(2,3-dihydro-1-benzofuran-7-ylcarbonyl)-1H-indazol-3-yl]-3-fluorobenzoic acid;
4-[1-(1-benzofuran-7-ylcarbonyl)-1H-indazol-3-yl]-3-fluorobenzoic acid;
4-{1-[(2-bromo-3-chlorophenyl)carbonyl]-1H-indazol-3-yl}-3-fluorobenzoic acid;
3-fluoro-4-(1-(tetrahydrofuran-2-carbonyl)-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(morpholine-4-carbonyl)-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-((2S,6R)-2,6-dimethylmorpholine-4-carbonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(4-oxopiperidine-1-carbonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
2-acetamido-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol -3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl) benzoyl)-6-(3-hydroxyazetidin-1-yl)-1H-indazol-3-yl)benzoic acid;
4-(6-(azetidin-1-yl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(cyclopropylamino)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(oxetan-3-ylamino)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxypyrrolidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-morpholino-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methoxycarbonylamino)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(N-methylacetamido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(cyclopropanecarboxamido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methylsulfonamido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methylureido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(6-acetamido-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(N-methylmethylsulfonamido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1,3-dimethylureido)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-oxo-imidazolidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-oxoazetidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(6-(2-carboxyethylamino)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methyl-2-oxoimidazolidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-oxopyrrolidin-1-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(morpholine-4-carbonyl)-1H-indazol-3-yl)benzoic acid;
3-(4-carboxyphenyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazole-6-carboxylic acid;
sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-methyloxazol-2-yl)-1H-indazol-3-yl)benzoate;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-methyloxazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxyprop-1-ynyl)-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxybut-1-ynyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(6-(3-aminoprop-1-ynyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-ethynyl-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methyl-1,2,4-oxadiazol-5-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-(hydroxymethyl)oxazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1-methyl-1H-imidazol-4-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(oxazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(6-(5-bromooxazol-2-yl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
(E)-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(N′-cyano-N,N-dimethylcarbamimidoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(4H-1,2,4-triazol-3-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(5-methyl-1,3,4-oxadiazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(1-methyl-1H-imidazol-2-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(1-methyl-1H-imidazol-5-yl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(5-methylthiophen-3-yl)-1H-indazol-3-yl]benzoic acid;
4-(1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-pyrimidin-2-yl-1H-indazol-3-yl)benzoic acid;
4-(1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-pyrimidin-4-yl-1H-indazol-3-yl)benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(1-methyl-1H-imidazol-4-yl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(1,3-thiazol-4-yl)-1H-indazol-3-yl]benzoic acid;
4-(6-[4-(aminomethyl)pyridin-2-yl]-1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-1H-indazol-3-yl)benzoic acid;
4-(1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-pyridin-2-yl-1H-indazol-3-yl)benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(1,3-thiazol-5-yl)-1H-indazol-3-yl]benzoic acid;
4-(1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-pyridin-4-yl-1H-indazol-3-yl)benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(4-cyanophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(3-cyanophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(2-cyanophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(2-fluorophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(3-fluorophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(4-fluorophenyl)-1H-indazol-3-yl]benzoic acid;
4-[1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-6-(1-methyl-1H-pyrazol-5-yl)-1H-indazol-3-yl]benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methylsulfonamidomethyl)-1H-indazol-3-yl)benzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2,5-dioxoimidazolidin-4-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(4-chloro-1-(2-chloro-6-cyclopropylbenzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-cyclopropylbenzoyl)-4-fluoro-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-2-methyl-1H-indol-3-yl)-3-fluorobenzoic acid;
4-(2-methyl-1-(2-(trifluoromethyl)benzoyl)-1H-indol-3-yl)benzoic acid;
4-(1-(2-chloro-6-cyclopropylbenzoyl)-1H-indazol-3-yl)-3,5-difluorobenzoic acid;
4-(1-(2-chloro-6-cyclopropylbenzoyl)-4-fluoro-1H-indazol-3-yl)-3,5-difluorobenzoic acid;
4-(6-(azetidine-1-carbonyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indol-3-yl)-3-fluorobenzoic acid;
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methoxy-azetidine-1-carbonyl)-1H-indol-3-yl)-3-fluorobenzoic acid; and
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(oxetan-3-yl)-1H-indazol-3-yl)-3-fluorobenzoic acid.

### Claim 21 (depends on 1)

A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt or solvate thereof, and one or more pharmaceutically acceptable excipients.

### Claim 22

(canceled)

### Claim 23

(canceled)

### Claim 24 (depends on 1)

A method for treating a disease or condition mediated by RORgammaT in a subject, comprising administering to the subject an amount of a compound of claim 1, or a pharmaceutically acceptable salt or solvate thereof, that is effective for treating the disease or condition mediated by RORgammaT in the subject, wherein the disease or condition is an autoimmune disease or inflammatory disease.

### Claim 25

(canceled)

### Claim 26 (depends on 1)

A method for treating a disease or condition mediated by RORgammaT in a subject, comprising administering to the subject an amount of a compound of claim 1, or a pharmaceutically acceptable salt or solvate thereof, that is effective for treating the disease or condition mediated by RORgammaT in the subject, wherein the disease or condition is multiple sclerosis, inflammatory bowel disease, Crohn's disease, ankylosing spondylitis, psoriasis, rheumatoid arthritis, asthma, osteoarthritis, Kawasaki disease, Hashimoto's thyroiditis, or mucosal leishmaniasis.

### Claim 27 (depends on 7)

The compound of claim 7, wherein:
R2 is C(O)OH;
R3 is hydrogen or halogen; and
R4, R5, and R7 are hydrogen or halogen.

### Claim 28 (depends on 27)

The compound of claim 27, wherein R6 is (C3-5)heterocycloalkylcarbonyl or (C3-5)heterocycloalkylcarbonyl(C1-4)alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O)—, (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl.

### Claim 29 (depends on 28)

A pharmaceutical composition comprising a compound of claim 28 or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.

### Claim 30

A compound according to the Formula:
or a pharmaceutically acceptable salt or solvate thereof, wherein:
Y is CH, CRa, or N;
n=0, 1, 2, 3 or 4;
A4 is CR4,
A5 is CR5,
A6 is CR6,
A7 is CR7,
Ra is (C1-4)alkyl or (C3-7)cycloalkyl;
R1 is
(i) (C3-12)carbocyclyl(C0-4)alkyl, or
(ii) a 4- to 12-membered heterocyclyl(C0-4)alkyl,
each optionally substituted with one, two, three, four or five R8;
R2 is hydroxycarbonyl, hydroxycarbonyl(C1-10)alkyl, (C1-10)alkylsulfoxyaminocarbonyl, or carbamoyl;
R3 is hydrogen, halogen, cyano, nitro, hydroxy, (C1-4)alkylcarbonyloxy, (C1-4) alkylsulfonylamino, (C1-4) alkylcarbonylamino, (C0-4) alkylamino, (C1-4)alkyl, hydroxyl(C1-4)alkyl or (C1-4)alkoxy, wherein (C1-4)alkyl and (C1-4)alkoxy are optionally substituted with one or more halogen;
R4, R5, and R7 independently are hydrogen, halogen, amino, cyano, hydroxy, (C1-3)alkoxy, (C1-4)alkyl, (C0-10)alkylaminocarbonyl, (C0-6)alkyoxycarbonylamino, (di)(C1-6)alkylaminocarbonyl, (C1-6)alkylcarbonylamino, (C1-4)alkylamino, amino(C1-4)alkyl or —C(O)H, wherein (C1-3)alkoxy, (C1-4)alkyl, (C0-10)alkyl)aminocarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkylamino and amino(C1-4)alkyl are optionally substituted with one or more halogen, hydroxyl or (C1-3)alkoxy; or a group having the formula
optionally substituted with one or more of the following: (C1-10)alkyl, halogen, amino, cyano, hydroxy, (C1-3)alkoxy, and wherein m is 1, 2, 3, or 4;
R6 is:
(i) (C3-7)cycloalkyl or (C3-5)heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(ii) (C2-9)heteroaryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(iii) (C6-14)aryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(iv) (C3-5)heterocycloalkylamino, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(v) (C3-5)cycloalkyl(C1-4)alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(vi) (C3-5)cycloalkylamino, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(vii) (C3-5)cycloalkylcarbonyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(viii) (C2-9)heteroaryl(C1-4)alkyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(ix) (C2-9)heteroarylcarbonyl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(x)
(xi) (C2-4)alkynyl, optionally substituted with one or more (C1-4alkyl, which (C1-4)alkyl may be substituted with hydroxyl or amino; or
(xii) Hydroxycarbonyl(C1-4alkylamino,
Hydroxycarbonyl,
(C1-6)alkylamino, or
(C1-6)alkoxyamino,
each optionally substituted with one or more (C1-4)alkyl, hydroxyl or amino; and
R8 is halogen, cyano, amino, nitro, hydroxy, oxo(═O), H2NC(O)—, di(C1-3)alkylamino, (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl, (C3-7)cycloalkyl, (C3-5)heterocycloalkyl, (C1-4)alkenyl, (C3-6)cycloalkoxy or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one, two or three halogens.

### Claim 31 (depends on 30)

The compound of claim 30, wherein:
Y is N;
R2 is C(O)OH;
R3 is hydrogen or halogen; and
R4, R5, and R7 are hydrogen or halogen.

### Claim 32 (depends on 31)

The compound of claim 31, wherein R6 is:
(i) (C3-7)cycloalkyl or (C3-5)heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, oxo (═O), H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl;
(ii) (C2-9)heteroaryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4)alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl; or
(iii) (C6-14)aryl, optionally substituted with one or more groups selected from halogen, amino, amino(C1-4)alkyl, cyano, nitro, hydroxyl, H2NC(O), (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4alkyl or (C1-3)alkoxy, wherein (C1-3)alkoxycarbonyl, (di)(C1-6)alkylaminocarbonyl, (C1-4alkyl and (C1-3)alkoxy are optionally substituted with one or more halogen, amino or hydroxyl.

### Claim 33 (depends on 30)

A pharmaceutical composition comprising a compound of claim 30 or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable excipients.