# US 2018/0021779 A1 · Device and methods using porous media in fluidic devices > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2018/0021779 A1 - Document ID: US20180021779A1 - Status: Published application - Kind: A1 - Application number: 15/702,007 - Filed: 2017-09-12 - Published: 2018-01-25 - Earliest claimed: 2014-09-18 - Assignees: Waters Technologies Corporation - Applicants: Waters Technologies Corporation - Inventors: Bernard Bunner; Martin Gilar; Robert A. Jencks; Charles T. Murphy - Web page: https://patentgrep.com/patent/US20180021779A1 ## CPC - B01L 3/502753: {characterised by bulk separation arrangements on lab-on-a-chip devices, e.g. for filtration or centrifugation} - B01L 3/502746: {characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves} - G01N 30/603: {retaining the stationary phase, e.g. Frits} - G01N 30/6095: {Micromachined or nanomachined, e.g. micro- or nanosize} - B01L 3/502707: {characterised by the manufacture of the container or its components} - B01L 3/502715: {characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces} - B01L 2200/027: for microfluidic devices - B01L 2300/0681: Filter - B01L 2400/0487: fluid pressure, pneumatics - B01L 2400/086: using baffles or other fixed flow obstructions - B01L: CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE - G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q) ## Abstract A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed. ## Claims ### Claim 1 An apparatus, comprising: a fluidic device having a fluidic channel and a cavity, the fluidic channel having a channel diameter to accommodate a fluid flow and the cavity having an open end in proximity to a surface of the fluidic device, wherein the cavity has a dimension that is substantially greater than the channel diameter and wherein the cavity is in fluid communication with the fluidic channel; and a pre-formed porous medium comprising a porous material disposed within the cavity, the porous medium having a porosity profile and being in fluid communication with the fluidic channel, wherein the fluid flow is directed through at least a portion of the pre-formed porous medium and wherein the porosity profile comprises an inner region having a first porosity and an outer region having a second porosity that differs from the first porosity, wherein the inner region and the outer region are aligned along a common axial reference location. ### Claim 2 (depends on 1) The apparatus of claim 1, wherein the fluidic device is a microfluidic device. ### Claim 3 (depends on 1) The apparatus of claim 1, wherein the inner region of the porous material has a higher porosity than the outer region of the porous material, wherein the inner region is in proximity to the fluidic channel, wherein the outer region is remote from the channel, and wherein the inner region extends between a top surface of the porous medium to a bottom surface of the porous medium, a difference between the higher porosity of the inner region and the porosity of the outer region directing a fluid flow through the porous medium in proximity to an opening of the fluidic channel to reduce fluid diffusion. ### Claim 4 (depends on 3) The device of claim 3, further comprising a packing material positioned within the fluidic channel and providing a stationary phase that separates compounds of a fluid of the fluid flow. ### Claim 5 (depends on 4) The apparatus of claim 4, further comprising an inlet, wherein the inlet is coupled with a solvent delivery system, a sample delivery system, a second porous medium, and a flow restrictor, wherein the second porous medium filters unwanted material from the solvent delivery system, and wherein the flow restrictor comprises a third porous medium that provides a target pressure for the fluid flow. ### Claim 6 (depends on 5) The apparatus of claim 5, wherein at least one of the second porous medium and the third porous medium comprises a uniform porosity profile. ### Claim 7 (depends on 1) The apparatus of claim 1, wherein the dimension of the cavity comprises a diameter that is at least about ten times greater than the channel diameter. ### Claim 8 An apparatus, comprising: a fluidic device having a fluidic channel and a cavity, the fluidic channel having a channel diameter to accommodate a fluid flow and the cavity having an open end in proximity to a surface of the fluidic device, wherein the cavity has a dimension that is substantially greater than the channel diameter and wherein the cavity is in fluid communication with the fluidic channel; and a porous medium comprising a porous material engaged in the cavity of the fluidic device and having a porosity profile, wherein the porosity profile comprises an inner region having a first porosity and an outer region having a second porosity that differs from the first porosity and wherein the inner region and the outer region are aligned along a common axial reference location. ### Claim 9 (depends on 8) The apparatus of claim 8, wherein the fluidic device comprises a microfluidic device, and wherein the porosity profile directs a fluid flow through the porous medium in proximity to an opening of the fluidic channel to reduce fluid diffusion. ### Claim 10 (depends on 8) The apparatus of claim 8, wherein the porosity profile is a non-uniform porosity profile that varies laterally across the porous medium. ### Claim 11 (depends on 8) The apparatus of claim 8, wherein the inner region of the porosity profile includes a higher porosity than the outer region of the porosity profile, wherein the inner region is in proximity to an opening of the fluidic channel, and wherein the outer region is remote from the opening of the fluidic channel, wherein the inner region extends from a fluid inlet surface of the porous medium to a fluid exit surface of the porous medium. ### Claim 12 (depends on 8) The apparatus of claim 8, wherein an opening of the fluidic channel is an inlet of the fluidic channel and wherein the porous material comprises sintered particles. ### Claim 13 (depends on 8) The apparatus of claim 8, further comprising providing a bed of particles in the fluidic device and wherein the porosity profile of the porous material prevents a flow of the bed of particles through the porous medium. ### Claim 14 (depends on 13) The apparatus of claim 13, wherein the fluidic device has a second cavity and wherein the second cavity is in fluid communication with the fluidic channel of the fluidic device, the apparatus further comprising a second porous medium having a porosity profile that allows flow of a fluid through the second porous medium and prevents flow of the bed of particles through the second porous medium. ### Claim 15 (depends on 8) The apparatus of claim 8, wherein the porosity profile comprises a sloped porosity profile in which a change in porosity between the inner region and the outer region varies according to a slope that directs a fluid flow through the porous medium in proximity to an opening of the channel to reduce fluid diffusion. ### Claim 16 (depends on 8) The apparatus of claim 8, wherein the porosity profile comprises a curved porosity profile in which a change in porosity between the inner region and the outer region varies according to a curve that directs a fluid flow through the porous medium in proximity to an opening of the fluid channel to reduce fluid diffusion. ### Claim 17 (depends on 8) The apparatus of claim 8, wherein the fluidic device is a microfluidic device. ### Claim 18 An apparatus, comprising: a fluidic device having a fluidic channel and a cavity, wherein the cavity is in fluid communication with the fluidic channel; and a porous medium disposed in the cavity of the fluidic device, the porous medium having a non-uniform porosity profile that provides different porosities at different radial displacements from a common reference location along a fluid axis, wherein the non-uniform porosity profile is selected for directing a fluid flow along the fluid axis through the porous medium in proximity to an opening of the fluidic channel to reduce fluid dispersion, wherein the non-uniformity porosity profile comprises a first region of the porous medium at a first radial displacement from the common reference location along the fluid axis having a higher porosity than a second region of the porous material at a second radial displacement from the common reference location along the fluid axis, wherein the first region is in proximity to the opening of the fluidic channel, wherein the second region is remote from the opening of the fluidic channel, and wherein the first region extends from a top surface of the porous medium to a bottom surface of the porous medium. ### Claim 19 (depends on 18) The apparatus of claim 18, wherein the different porosities at the different radial displacements vary according to a sloped porosity profile that directs a fluid flow through the porous medium in proximity to the opening of the fluidic channel to reduce fluid diffusion away from the opening of the fluidic channel. ### Claim 20 (depends on 18) The apparatus of claim 18, wherein the different porosities at the different radial displacements vary according to a curved porosity profile that directs a fluid flow through the porous medium in proximity to the opening of the fluidic channel to reduce fluid diffusion away from the opening of the fluidic channel. ### Claim 21 (depends on 18) The apparatus of claim 18, wherein the different porosities at the different radial displacements vary according to a stepped porosity profile that directs a fluid flow through the porous medium in proximity to the opening of the fluidic channel to reduce fluid diffusion away from the opening of the fluidic channel. ### Claim 22 (depends on 18) The apparatus of claim 18, wherein the fluidic device is a microfluidic device.