# US 2018/0021695 A1 · Carbon Block/Filtration Bed/Conical Reactor with Fluidized Bed System Allowing Small Sorbent Particles to Regenerate Fluid During Extracorporeal Blood Treatment > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2018/0021695 A1 - Document ID: US20180021695A1 - Status: Published application - Kind: A1 - Application number: 15/624,703 - Filed: 2017-06-15 - Published: 2018-01-25 - Earliest claimed: 2016-06-15 - Assignees: Hemocleanse Technology LLC - Inventors: STEPHEN ASH; TOM SULLIVAN; DAVID CARR - Web page: https://patentgrep.com/patent/US20180021695A1 ## CPC - B01D 15/02: with moving adsorbents - A61M 1/1696: {with dialysate regeneration} - A61M 1/28: Peritoneal dialysis {; Other peritoneal treatment, e.g. oxygenation} - A61M 1/3486: {Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents} - A61M 1/3679: {by absorption (A61M1/3675 takes precedence)} - B01J 20/0259: {Compounds of N, P, As, Sb, Bi} - B01J 20/20: comprising free carbon; comprising carbon obtained by carbonising processes - B01J 20/28004: {Sorbent size or size distribution, e.g. particle size} - B01J 20/28033: {Membrane, sheet, cloth, pad, lamellar or mat} - B01J 20/28042: {Shaped bodies; Monolithic structures} - B01D: SEPARATION (separating solids from solids by wet methods B03B, B03D; by pneumatic jigs or tables B03B; by other dry methods B07; magnetic or electrostatic separation of solid materials from solid materials or fluids, separation by high-voltage electric fields B03C; centrifuges, vortex apparatus B04; presses per se for squeezing-out liquid from liquid-containing material B30B9/02; treatment of water C02F, e.g. softening by ion-exchange C02F1/42; {arrangements of air intake cleaners in gas turbine plants F02C7/05} ; arrangements or mounting of filters in air-conditioning, air-humidification or ventilation F24F13/28) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - B01J: CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS ## Abstract Methods and devices for powdered sorbent regeneration of biologic fluids are disclosed. The present invention includes three novel methods, which may be used singly or in any combination, for constraining or immobilizing powders so that they can be perfused with a biological fluid or dialysate: a porous carbon block filter, a filtration bed of very fine powder, and a cone-shaped reactor. ## Claims ### Claim 1 A regeneration system for a biologic fluid in extracorporeal blood treatment comprising: a housing comprising an interior volume and at least one inlet and at least one outlet; a solid filtration module comprising a surface adsorptive agent positioned within the housing between the inlet and the interior volume; a bed of sorbent particles positioned within the housing between the filtration block and the outlet; and a cone shaped reactor placed below the solid filtration module to create a fluidized bed within it, keeping most of the larger sorbent particles within the reactor and allowing the fine particles to flow with perfusing solution to form the above bed of particles. ### Claim 2 (depends on 1) The regeneration system of claim 1, wherein the filtration module and bed of sorbent particles are arranged within the housing relative to the inlet and outlet such that fluid entering the housing through the inlet fluidizes the bed of sorbent particles, and passes through the filtration block before exiting the housing though the outlet, and the cone shaped reactor is placed below the filtration module, allowing collection of sorbent particles from the filtration bed which fall off of the filtration module when flow is stopped. ### Claim 3 (depends on 1) The regeneration system of claim 1, wherein the sorbent particles do not penetrate the filtration module to exit the housing through the outlet. ### Claim 4 (depends on 1) The regeneration system of claim 1, wherein the filtration module comprises activated carbon. ### Claim 5 (depends on 1) The regeneration system of claim 1, wherein the filtration module comprises a body of compressed activated carbon particles. ### Claim 6 (depends on 5) The regeneration system of claim 5, wherein the filtration module is a porous activated carbon body selected from the group consisting of a carbon block, a carbon fiber pad, and a nanofiber felt. ### Claim 7 (depends on 6) The regeneration system of claim 6, wherein the filtration module may further comprise a membrane, screen, filter, or other means, with which to constrain sorbent particles. ### Claim 8 (depends on 1) The regeneration system of claim 1, wherein the sorbent particles comprise calcium phosphate particles, microporous zirconium silicate, an immune-sorbent, or a sorbent capable of binding endotoxin and TNF. ### Claim 9 (depends on 1) The regeneration system of claim 1, wherein the sorbent particles comprise particles of one or more ion exchange substances, one or more physiological electrolyte substances, one or more macromolecular flow inducing agents, or combination thereof. ### Claim 10 (depends on 1) The regeneration system of claim 1, wherein the sorbent particles have a particle size of 1-50 microns. ### Claim 11 (depends on 1) The regeneration system of claim 1, wherein the sorbent particles are present in the housing in a volume ratio to create a bed of fine sorbent particles around the filtration bed of 2-6 mm. ### Claim 12 (depends on 6) The regeneration system of claim 6, wherein the carbon block comprises small pieces of carbon which have high external surface area, and fine features which give a short mean pore path length, but which are constrained or immobilized in a manner to allow perfusion of fluids around every particle. ### Claim 13 (depends on 6) The regeneration system of claim 6, wherein the filtering surface of the carbon block restrains very small particles of other sorbents besides charcoal. ### Claim 14 (depends on 1) The regeneration system of claim 1, wherein the biologic fluid is blood, dialysate, peritoneal fluid, ultrafiltrate, or plasma. ### Claim 15 (depends on 1) The regeneration system of claim 1, wherein the bed of sorbent particles is created by passing a fluid containing suspended particles through the filtering surface of the carbon block or a similar filter, and holding the particles in fixed position by continuous flow. ### Claim 16 (depends on 1) The regeneration system of claim 1, wherein the bed of sorbent particles allows particles to be used for perfusion and depuration, as in a column. ### Claim 17 (depends on 16) The regeneration system of claim 16, wherein the bed of sorbent particles provides even flow distribution within the layer of very small particles. ### Claim 18 (depends on 1) The regeneration system of claim 1, wherein the fine sorbent particles are suspended by an upward flow of dialysate or biological fluid that exactly equals the sedimentation rate of fine particles. ### Claim 19 (depends on 15) The regeneration system of claim 15, wherein the suspended particles move around within the fluid, mixing evenly with all the passing fluid. ### Claim 20 (depends on 1) The regeneration system of claim 1, wherein the conical shape of the reactor provides a continuously decreasing upward velocity of fluid flow, to create one level where the majority of sorbent particles do not pass upwards. ### Claim 21 (canceled) ### Claim 22 (canceled) ### Claim 23 (canceled) ### Claim 24 (canceled) ### Claim 25 (canceled) ### Claim 26 (canceled) ### Claim 27 (canceled) ### Claim 28 (canceled) ### Claim 29 (canceled) ### Claim 30 (canceled) ### Claim 31 (canceled) ### Claim 32 (canceled) ### Claim 33 (canceled) ### Claim 34 (canceled) ### Claim 35 (canceled) ### Claim 36 (canceled) ### Claim 37 (canceled) ### Claim 38 (canceled) ### Claim 39 (canceled) ### Claim 40 (canceled) ### Claim 41 (canceled) ### Claim 42 (canceled) ### Claim 43 (canceled) ### Claim 44 (canceled) ### Claim 45 (canceled) ### Claim 46 (canceled) ### Claim 47 (canceled) ### Claim 48 (canceled) ### Claim 49 (canceled) ### Claim 50 (canceled) ### Claim 51 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