# US 2018/0021389 A1 · Synergistic composition comprising propolis and carnosic acid for use in the prevention and treatment of candidiasis

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- Number: US 2018/0021389 A1
- Document ID: US20180021389A1
- Status: Published application
- Kind: A1
- Application number: 15/546,879
- Filed: 2015-02-04
- Published: 2018-01-25
- Earliest claimed: 2015-02-04
- Assignees: Vitalgaia Espana, S.L
- Applicants: Vitalgaia Espana, S.L
- Inventors: Jose Antonio LOZANO TERUEL; Juan Carlos ARGUELLES ORDONEZ; Alejandra ARGUELLES PRIETO; Ruth SANCHEZ-FRESNEDA PINTO; Jose Pedro GUIRAO ABAD
- Web page: https://patentgrep.com/patent/US20180021389A1

## CPC

- A61K 35/644: Beeswax; Propolis; Royal jelly; Honey
- A23G 3/364: {containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins}
- A23G 3/48: containing plants or parts thereof, e.g. fruits, seeds, extracts (containing gums A23G3/42)
- A23G 4/068: {containing plants or parts thereof, e.g. fruits, seeds, extracts (containing gums A23G4/10)}
- A23G 4/12: containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins (containing dairy products A23G4/16)
- A23K 20/10: Organic substances
- A23K 20/111: Aromatic compounds
- A23L 21/20: Products from apiculture, e.g. royal jelly or pollen; Substitutes therefor
- A23L 33/10: using additives (addition of substantially indigestible substances A23L33/21)
- A23L 33/105: Plant extracts, their artificial duplicates or their derivatives
- A61K 31/192: having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid {(cannabinoids A61K31/658)}
- A61P 31/10: Antimycotics
- A23V 2002/00: Food compositions, function of food ingredients or processes for food or foodstuffs
- A61K 9/06: Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)}
- A61K 9/10: Dispersions; Emulsions
- A61K 9/12: Aerosols; Foams {(A61K9/0043, A61K9/0056, A61K9/006, A61K9/0073 take precedence; spray-films A61K9/7015)}
- A61K 9/2054: {Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose}
- A61K 9/4866: {Organic macromolecular compounds}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A23G: COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23K: FODDER
- A23L: FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF (preservation thereof A23B)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A23V: INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION

## Abstract

Synergistic composition comprising propolis and carnosic acid for use in the prevention and treatment of candidiasis. The invention relates to a synergistic composition comprising propolis that comprises polyphenols at a concentration between 70 and 90% by weight of propolis and carnosic acid, for use in the prevention and treatment of candidiasis in humans and/or animals. The invention also relates to a synergistic pharmaceutical and/or veterinary composition and a synergistic food product.

## Claims

### Claim 1

A synergistic composition comprising:
propolis comprising polyphenols at a concentration between 70 and 90% by weight of the propolis and
carnosic acid,
for use in the prevention and treatment of candidiasis in humans and/or animals.

### Claim 2 (depends on 1)

Synergistic composition for use according to claim 1, wherein the candidiasis is epithelial candidiasis.

### Claim 3 (depends on 1)

Synergistic composition for use according to claim 1, wherein the concentration of propolis is between 20 and 80% by weight relative to the total of the synergistic composition.

### Claim 4 (depends on 1)

Synergistic composition for use according to claim 1, wherein the concentration of carnosic acid is between 10 and 60% by weight relative to the total of the synergistic composition.

### Claim 5 (depends on 1)

Synergistic composition for use according to claim 1, wherein the synergistic composition is provided in the form selected from the group consisting of cream, gel, ointment, vaginal suppositories, sprays, tablets, powders for topical use, capsules, powder for oral suspension, ear drops, toothpaste, mouthwash, perfusion, syrup, wipes, dental thread, dental floss, toothbrush and interdental brush.

### Claim 6

Synergistic pharmaceutical and/or veterinary composition comprising:
propolis comprising polyphenols at a concentration between 70 and 90% by weight of the propolis and
carnosic acid,
together with pharmaceutically and/or veterinarily acceptable excipients, for use in the prevention and treatment of candidiasis in humans and/or animals.

### Claim 7 (depends on 6)

Synergistic pharmaceutical and/or veterinary composition for use according to claim 6, wherein the concentration of propolis is between 20 and 80% by weight relative to the total of the synergistic pharmaceutical and/or veterinary composition.

### Claim 8 (depends on 6)

Synergistic pharmaceutical and/or veterinary composition for use according to claim 6, wherein the concentration of carnosic acid is between 10 and 60% by weight relative to the total of the synergistic pharmaceutical and/or veterinary composition.

### Claim 9 (depends on 6)

Synergistic pharmaceutical and/or veterinary composition for use according to claim 6, wherein said excipients are selected from the group consisting of agglutinants, fillers, disintegrants, lubricants, coatings, sweeteners, flavouring, colouring agents, sugars, xylitol, calcium phosphate, fat spheroids, talc, polysorbate, propylene glycol, isopropyl alcohol, microcrystalline cellulose, magnesium stearate, lactose, monohydrate lactose, rice starch, maltodextrins, lauryl sodium sulfate, sorbitol, light precipitated calcium carbonate, sodium bicarbonate, sodium silicate solution, sodium saccharin, sodium carboxymethyl cellulose, light mineral oil, purified water, colloidal silica, sucrose, anhydrous colloidal silica, gum arabic, sodium citrate, anhydrous citric acid, sodium chloride, sodium hydroxide, glycerine, hydroalcoholic with glyceryl polymethacrylate, eudermic surfactants, ethanol and benzalkonium chloride.

### Claim 10

Synergistic food product comprising
propolis comprising polyphenols at a concentration between 70 and 90% by weight of the propolis and
carnosic acid,
for use in the prevention and treatment of candidiasis in humans and/or animals.

### Claim 11 (depends on 10)

Synergistic food product according to claim 10, wherein the food product is provided in the form selected from the group consisting of chewing gum, gumdrops, lollipops and sweets.

### Claim 12 (depends on 10)

Synergistic food product according to claim 10, wherein the concentration of propolis is between 20 and 80% by weight relative to the total of the food product.

### Claim 13 (depends on 10)

Synergistic food product according to claim 10, wherein the concentration of carnosic acid is between 10 and 60% by weight relative to the total of the food product.

### Claim 14 (depends on 1)

A method for treating candidiasis in a mammal comprising administering the synergistic composition of claim 1 to the mammal in need thereof.

### Claim 15 (depends on 14)

The method according to claim 14, wherein the mammal is a human or an animal.

### Claim 16 (depends on 14)

The method according to claim 14, wherein the candidiasis is epithelial candidiasis.

### Claim 17 (depends on 14)

The method according to claim 14, wherein the concentration of propolis is between 20 and 80% by weight relative to the total of the synergistic composition.

### Claim 18 (depends on 14)

The method according to claim 14, wherein the concentration of the carnosic acid is between 10 and 60% by weight relative to the total of the synergistic composition.

### Claim 19 (depends on 14)

The method according to claim 14, wherein the synergistic composition further comprises pharmaceutical or veterinary acceptable excipients.

### Claim 20 (depends on 19)

The method according to claim 19, wherein the excipients are selected from the group consisting of agglutinants, fillers, disintegrants, lubricants, coatings, sweeteners, flavouring, colouring agents, sugars, xylitol, calcium phosphate, fat spheroids, talc, polysorbate, propylene glycol, isopropyl alcohol, microcrystalline cellulose, magnesium stearate, lactose, monohydrate lactose, rice starch, maltodextrins, lauryl sodium sulfate, sorbitol, light precipitated calcium carbonate, sodium bicarbonate, sodium silicate solution, sodium saccharin, sodium carboxymethyl cellulose, light mineral oil, purified water, colloidal silica, sucrose, anhydrous colloidal silica, gum arabic, sodium citrate, anhydrous citric acid, sodium chloride, sodium hydroxide, glycerine, hydroalcoholic with glyceryl polymethacrylate, eudermic surfactants, ethanol and benzalkonium chloride.