# US 2018/0021377 A1 · Platelet concentrate for increase of cell regeneration and cell growth

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- Number: US 2018/0021377 A1
- Document ID: US20180021377A1
- Status: Published application
- Kind: A1
- Application number: 15/544,876
- Filed: 2016-01-21
- Published: 2018-01-25
- Earliest claimed: 2015-01-21
- Assignees: Edvin Turkof
- Inventors: Markus Dettke; Arthur Adler
- Web page: https://patentgrep.com/patent/US20180021377A1

## CPC

- A61K 35/16: Blood plasma; Blood serum (umbilical cord blood A61K35/51)
- A61K 8/983: {Blood, e.g. plasma}
- A61P 17/14: for baldness or alopecia
- A61Q 5/002: {Preparations for repairing the hair, e.g. hair cure}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS

## Abstract

The invention refers to a decomposed platelet concentrate containing ≦50% intact platelets and optionally ≧200 pg/ml RANTES and specifically to its use in the prevention or treatment of hair loss and/or for promoting hair growth. The invention further refers to a composition comprising the decomposed platelet concentrate and body fat cells and the use of said composition for reconstructive and aesthetic and curative surgery and pain relief treatment.

## Claims

### Claim 1

A method of preventing or treating hair thinning or hair loss and/or for promoting hair growth, comprising administering a decomposed platelet concentrate containing <50% intact platelets to a subject in need thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the hair loss is selected from the group consisting of cicatricial alopecia, androgenic alopecia, and alopecia areata.

### Claim 3 (depends on 1)

The method of claim 1, wherein the hair bulb cells and/or scalp are regenerated.

### Claim 4 (depends on 1)

The method of claim 1, wherein the platelet concentrate is administered topically, intra-dermally, or subdermally.

### Claim 5 (depends on 1)

The method of claim 1, wherein the decomposed platelet concentrate is obtained by freeze thawing of a platelet fraction.

### Claim 6 (depends on 5)

The method of claim 5, wherein the platelet fraction is obtained from an apheresis fraction, specifically from a thrombocytapheresis fraction.

### Claim 7 (depends on 1)

The method of claim 1, wherein the platelet concentrate contains <40%, specifically <30%, specifically <20%, specifically <10% intact platelets, specifically <1% intact platelets, specifically the platelet concentrate is free of intact platelets.

### Claim 8

A composition comprising a decomposed platelet concentrate containing <50% intact platelets and >200 pg/ml RANTES.

### Claim at position 9

9-10. (canceled)

### Claim 11 (depends on 8)

The composition of claim 8, further comprising body fat cells.

### Claim 12 (depends on 11)

The composition of claim 11, wherein the body fat cells are from lipoaspirate.

### Claim 13 (depends on 11)

The composition of claim 11, wherein the body fat cells and the platelet concentrate are from the same donor.

### Claim 14 (depends on 11)

The composition of claim 11, wherein the volume ratio of body fat cells and platelet concentrate is between 10:1 and 4:1, specifically between 5:1 and 3:1.

### Claim at position 14

15-16. (canceled)

### Claim 17 (depends on 1)

The method of claim 1, wherein the platelet concentrate is of autologous, allogenic or synthetic origin.

### Claim 18 (depends on 1)

The method of claim 1, wherein the platelet concentrate is formulated as a balm, solution, suspension, emulsion, ointment, foam, past, gel, cream, lotion, powder or salve.

### Claim 19 (depends on 1)

The method of claim 1, wherein the platelet concentrate is administered repeatedly.

### Claim at position 18

20-21. (canceled)

### Claim 22 (depends on 11)

A method for performing surgery, wherein the composition of claim 11 is administered to a patient in need thereof to augment volume of a tissue.

### Claim 23 (depends on 22)

The method of claim 22, wherein the composition is an autologous composition.

### Claim 24

(canceled)

### Claim 25 (depends on 22)

The method of claim 22, wherein the tissue is breast tissue.