# US 2018/0021249 A1 · Microorganisms inhibiting the formation of foot malodor

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- Number: US 2018/0021249 A1
- Document ID: US20180021249A1
- Status: Published application
- Kind: A1
- Application number: 15/450,474
- Filed: 2017-03-06
- Published: 2018-01-25
- Earliest claimed: 2005-09-19
- Assignees: BASF SE
- Applicants: BASF SE
- Inventors: Andreas REINDL; Rolf KNÖLL; Christine LANG; Markus VEEN; Eckhard BUDDE; Mewes BOETTNER
- Web page: https://patentgrep.com/patent/US20180021249A1

## CPC

- A61K 8/99: from microorganisms other than algae or fungi, e.g. protozoa or bacteria
- A61K 35/74: Bacteria (therapeutic use of a bacterial protein A61K38/00)
- A61K 35/744: Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K 35/747: Lactobacilli, e.g. L. acidophilus or L. brevis
- A61P 17/00: Drugs for dermatological disorders
- A61Q 15/00: Anti-perspirants or body deodorants (deodorisation of air A61L9/00)
- C12N 1/20: Bacteria; Culture media therefor
- C12N 1/205: Bacterial isolates
- C12R 2001/225: Lactobacillus
- C12R 2001/24: Lactobacillus brevis
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS

## Abstract

Described are microorganisms which are able to inhibit the formation of foot malodor by skin microorganisms. Also described are compositions comprising such microorganisms as well as the use of such microorganisms in cosmetic, prophylactic or therapeutic applications.

## Claims

### Claim 1

A microorganism which is able to prevent the generation of foot malodor by skin microorganisms.

### Claim 2 (depends on 1)

The microorganism of claim 1 which is able to prevent the generation of foot malodor by skin microorganisms in a sniffing assay.

### Claim 3 (depends on 1)

The microorganism of claim 1 which is able to suppress the biosynthesis of isovaleric acid by skin microorganisms.

### Claim 4 (depends on 3)

The microorganism of claim 3, which is able to suppress the biosynthesis of isovaleric acid by skin microorganisms in an assay comprising the following steps:
(i) mixing said microorganism with a microorganism which is capable of generating isovaleric acid and with a precursor of isovaleric acid;
(ii) incubating the mixture under conditions allowing the generation of isovaleric acid;
(iii) extracting short fatty acids from the supernatant of the mixture; and
(iv) detecting the generation of foot malodor by the occurrence of isovaleric acid.

### Claim 5 (depends on 3)

The microorganism of claim 3, wherein isovaleric acid is generated by a bacterium of the genus Micrococcus or Propionibacterium.

### Claim 6 (depends on 5)

The microorganism of claim 5, wherein the Propionibacterium is Propionibacterium freudenreichii.

### Claim 7 (depends on 1)

The microorganism of claim 1, which is able to inhibit the growth of foot malodor generating skin microorganisms.

### Claim 8 (depends on 7)

The microorganism of claim 7, which is able to inhibit the growth of foot malodor generating skin microorganisms in an inhibition assay.

### Claim 9 (depends on 1)

The microorganism of claim 1, which belongs to a genus selected from the group consisting of Lactobacillus, Lactococcus and Leuconostoc.

### Claim 10 (depends on 9)

The microorganism of claim 9, which is selected from the group consisting of Lactobacillus brevis, Lactobacillus plantarum, Lactobacillus curvatus, Lactobacillus delbrückii delbrückii, and Leuconostoc mesenteroides.

### Claim 11 (depends on 10)

The microorganism of claim 10, which is selected from the group consisting of Lactobacillus brevis LB-FG-0001 (DSM 17599), Lactobacillus plantarum LB-FG-0002 (DSM 17600), Lactobacillus curvatus LB-FG-0003 (DSM 17601), Leuconostoc mesenteroides LB-FG-0004 (DSM 17602), Lactobacillus plantarum LB-FG-0005 (DSM 17603), Lactobacillus delbrückii delbrückii LB-FG-0006 (DSM 17604), Lactobacillus delbrückii delbrückii LB-FG-0007 (DSM 17605), Lactobacillus plantarum LB-FG-0008 (DSM 17606) and Lactobacillus brevis, LB-FG-0009 (DSM 17607).

### Claim 12 (depends on 10)

The microorganism of claim 10, which is a mutant of the selected microorganism that retains the ability to prevent the generation of foot malodor by skin microorganisms

### Claim 13 (depends on 10)

An inactive form of the microorganism of claim 10, which is able to prevent the generation of foot malodor by skin microorganisms.

### Claim 14 (depends on 11)

An inactive form of the microorganism of claim 11, which is able to prevent the generation of foot malodor by skin microorganisms.

### Claim 15 (depends on 13)

The inactive form of claim 13, which is thermally inactivated or lyophilized.

### Claim 16 (depends on 1)

A composition comprising the microorganism of claim 1.

### Claim 17 (depends on 16)

A cosmetic composition, which comprises the composition of claim 16 and a cosmetically acceptable carrier or excipient.

### Claim 18 (depends on 16)

A pharmaceutical composition, which comprises the composition of claim 16 and a pharmaceutically acceptable carrier or excipient.

### Claim 19 (depends on 1)

A method for the production of a cosmetic composition comprising the step of formulating the microorganism of claim 1 with a cosmetically acceptable carrier or excipient.

### Claim 20 (depends on 1)

A method for the production of a pharmaceutical composition comprising the step of formulating the microorganism of claim 1 with a pharmaceutically acceptable carrier or excipient.