# US 2018/0021226 A1 · Microcomplex for Use in Photoepilation Process to Obtain it and Composition Containing it

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- Number: US 2018/0021226 A1
- Document ID: US20180021226A1
- Status: Published application
- Kind: A1
- Application number: 15/543,763
- Filed: 2015-01-14
- Published: 2018-01-25
- Earliest claimed: 2015-01-14
- Assignees: Fundació Institut De CièNcies FotòNiques; Institució Catalana De Recerca I Estudis AvançAts
- Applicants: Fundació Institut de Ciències Fotòniques; Institució Catalana de Recerca I Estudis Avançats
- Inventors: Ignacio De Miguel; Romain Quidant
- Web page: https://patentgrep.com/patent/US20180021226A1

## CPC

- A61K 8/0245: {Specific shapes or structures not provided for by any of the groups of A61K8/0241}
- A61K 8/19: containing inorganic ingredients
- A61K 8/25: Silicon; Compounds thereof
- A61K 8/736: {Chitin; Chitosan; Derivatives thereof}
- A61Q 9/04: Depilatories
- A61B 18/203: {applying laser energy to the outside of the body}
- A61B 2018/00476: {Hair follicles}
- A61K 2800/413: Nanosized, i.e. having sizes below 100 nm
- A61K 2800/61: Surface treated
- A61K 2800/624: by macromolecular compounds
- A61K 2800/651: The particulate/core comprising inorganic material
- A61K 2800/81: Preparation or application process involves irradiation
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D)

## Abstract

The present invention relates to a microcomplex containing a modified nanoparticle adsorbed on a host microparticle and to a process to obtain it. The microcomplex is particularly useful for photoepilation. The present invention also relates to a composition containing the microcomplex and to the method for enhanced photoepilation based on the microcomplexes.

## Claims

### Claim 1

A microcomplex for use in photoepilation comprising:
a nanocomplex which comprise a nanoparticle of a material selected from the group consisting of metals, semiconductors and their mixtures, supporting a Localized Surface Plasmon Resonance, which is coated by forming at least a bond, coordinative or covalent, with at least a polycationic polymer or a heterobifunctional compound which comprises at least a thiol group on one extreme of the molecule and at least a positively charged functional group on the other extreme; adsorbed on the surface of a host particle with a diameter comprised between 100 nm and 2000 nm; the microcomplex have a Z potential higher than 10 mv.

### Claim 2 (depends on 1)

The microcomplex according to claim 1 wherein the diameter of the host particle is comprised between 200 nm and 500 nm.

### Claim 3 (depends on 2)

The microcomplex according to claim 2 wherein the host particle is silica.

### Claim 4 (depends on 3)

The microcomplex according to claim 3 wherein the modified silica is a modified silica with amines group.

### Claim 5 (depends on 1)

The microcomplex according to claim 1, wherein the microcomplex presents a localized surface plasmon resonance maximum between 700 and 900 nm.

### Claim 6 (depends on 1)

The microcomplex according to claim 1 wherein the nanoparticle is a gold nanorod.

### Claim 7 (depends on 1)

The microcomplex according to claim 1, wherein the polycationic polymer is a polyamine or polyimine containing polymer.

### Claim 8 (depends on 7)

The microcomplex according to claim 7 wherein the polycationic polymer is chitosan or polyethyleneimine.

### Claim 9 (depends on 1)

A process for the preparation of the microcomplex according to claim 1, which comprises:
a) adding a suspension of nanoparticle coated with at least a polycationic polymer to a host microparticle with a diameter comprises between 100 nm and 2000 nm, under ultrasounds, and b) separating the microcomplexes obtained in the step a).

### Claim 10 (depends on 1)

A process for the preparation of the microcomplex according to claim 1, which comprises: a) mixing amino modified host microspheres with a diameter comprises between 100 nm and 2000 nm with a surfactant coated nanoparticles, b) sonicating the suspension obtained in the step a) c) incubating under stirring, and d) coating the resulting microcomplex with a polycationic polymer.

### Claim 11 (depends on 1)

A composition comprising the microcomplex as defined in claim 1.

### Claim 12 (depends on 11)

Photoepilation method which comprises the steps of (i) applying to the skin surface the composition for topical application as defined in claim 11, and (ii) applying a radiation from a radiation source to said surface of the skin.

### Claim 13 (depends on 12)

Photoepilation method as described in claim 12 on which the radiation source is a LED device emitting in a wavelength ranging from 700 to 1200 nm.

### Claim 14 (depends on 1)

Use of microcomplex as defined in claim 1, in a photoepilation method.