# US 2018/0021005 A1 · Automated quantitative imaging system > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2018/0021005 A1 - Document ID: US20180021005A1 - Status: Published application - Kind: A1 - Application number: 15/520,874 - Filed: 2015-10-15 - Published: 2018-01-25 - Earliest claimed: 2014-10-27 - Assignees: Koninklijke Philips N.V. - Applicants: Koninklijke Philips N.V. - Inventors: Joseph CONNER; Charles NORTMANN; Lingxiong SHAO - Web page: https://patentgrep.com/patent/US20180021005A1 ## CPC - A61B 6/545: {involving automatic set-up of acquisition parameters} - A61B 6/00: Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment (instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161) - A61B 6/03: Computed tomography [CT] - A61B 6/037: {Emission tomography} - A61B 6/486: {involving generating temporal series of image data} - A61B 6/5205: {involving processing of raw data to produce diagnostic data} - A61B 6/582: {Calibration} - A61M 5/007: {for contrast media} - A61M 5/172: electrical or electronic - A61M 5/5086: {for indicating if defective, used, tampered with or unsterile} - G06T 12/00: Tomographic reconstruction from projections - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} - G06T: IMAGE DATA PROCESSING OR GENERATION, IN GENERAL ## Abstract A quantitative imaging system (100) for automating delivery of a radiopharmaceutical and imaging a patient. The system (100) includes a QI controller (102) that controls the operation of the system. The system (100) includes a producer (104) for creating a radiopharmaceutical and a synthesizer (106) to synthesize the radioisotope with a biologically compatible material to form the radiopharmaceutical. The system (100) includes a dosimeter (110) to measure and timestamp the concentration measurement of the radiopharmaceutical and an injector (112) to deliver the radiopharmaceutical into the patient. The system (100) includes an imaging apparatus (114) to image the patient. The QI controller (102) uses the timestamp of the concentration and decay characteristics to adjust imaging data. The system includes aquantitative analyzer (116) to calculate parametric images and quantitative values from the collected data. ## Claims ### Claim 1 A quantitative imaging system comprising: a delivery mechanism configured to deliver a radiopharmaceutical to a subject; an imaging apparatus configured to image the subject; and a quantitative controller communicatively linked to the delivery mechanism and imaging apparatus. ### Claim 2 (depends on 1) The quantitative imaging system according to claim 1, wherein the delivery mechanism includes: the delivery mechanism configured to create a radiopharmaceutical for a subject. ### Claim 3 (depends on 1) The quantitative imaging system according to claim 1, wherein the delivery mechanism further includes: a dose calibrator configured to sample the radiopharmaceutical for a concentration measurement of radioactive isotopes in the radiopharmaceutical and timestamps the measurement. ### Claim 4 (depends on 1) The quantitative imaging system according to claim 1, wherein the delivery mechanism further includes: a producer configured to convert a precursor material input into radioisotope; and a synthesizer configured to synthesize the radioisotope with a biologically compatible material to form the radiopharmaceutical. ### Claim 5 (depends on 4) The quantitative imaging system according to claim 4, wherein the delivery mechanism further includes: an injector configured to inject the radiopharmaceutical into the subject, wherein the producer the synthesizer, the injector and the delivery mechanism are interconnected to convey the radioisotope to the synthesizer and the radiopharmaceutical between the synthesizer, the dose calibrator and the delivery mechanism automatically without human intervention. ### Claim 6 (depends on 2) The quantitative imaging system according to claim 2, wherein the QI controller is configured to adjust imaging data generated by the imaging apparatus based on the time the dose calibrator measured the concentration of the radioisotope and radiation decay characteristics of the radioisotope. ### Claim 7 (depends on 2) The quantitative imaging system according to claim 2, wherein the QI controller uses the timestamp for controlling the delivery to the patient. ### Claim 8 (depends on 2) The quantitative imaging system according to claim 2, wherein the imaging apparatus is configured to generate a temporal series of timestamped images and the imaging system and/or the QI controller are configured to adjust the images based on the timestamps of the concentration measurement and the images and radiation decay characteristics of the radioisotope. ### Claim 9 (depends on 8) The quantitative imaging system according to claim 8, wherein the QI controller reconstructs the adjusted imaging data into images of the patient. ### Claim 10 (depends on 2) The quantitative imaging system according to claim 2, wherein the QI controller discards the radiopharmaceutical after determining it has lost too much radiation between the time of the timestamp and the time for injecting the patient. ### Claim 11 A method for quantitative imaging a patient, comprising: delivering a radiopharmaceutical to a patient; receiving imaging data of a patient; and controlling the delivery of the radiopharmaceutical and imaging of the patient. ### Claim 12 (depends on 11) The method according to claim 11, including: creating a radiopharmaceutical for a patient. ### Claim 13 (depends on 11) The method according to claim 11, wherein delivering the radiopharmaceutical includes: sampling the radiopharmaceutical for a concentration measurement of radioactive isotopes in the radiopharmaceutical; and timestamping the measurement. ### Claim 14 (depends on 13) The method according to claim 13, including: converting a precursor material input into radioisotope; and synthesizing the radioisotope with a biologically compatible material to form the radiopharmaceutical. ### Claim 15 (depends on 14) The method according to claim 14, including: injecting the radiopharmaceutical into the subject, wherein the production, the synthesizing, the injection and the delivery are interconnected to convey the radioisotope for synthesis and the radiopharmaceutical between synthesis, the concentration measurement and delivery automatically without human intervention. ### Claim 16 (depends on 12) The method according to claim 12, including: generating imaging data of the subject; and adjusting the imaging data based on time since the concentration measurement of the radioisotope and radiation decay characteristics of the radioisotope. ### Claim 17 (depends on 12) The method according to claim 12, including: controlling the delivery to the patient using the timestamp. ### Claim 18 (depends on 12) The method according to claim 12, including: generating a temporal series of timestamped images; and adjusting the images based on the timestamps of the concentration measurement and the images and radiation decay characteristics of the radioisotope. ### Claim 19 (depends on 19) The method according to claim 19, including: reconstructing the adjusted imaging data into diagnostic images of the patient. ### Claim 20 (depends on 11) The method according to claim 11, including: discarding the radiopharmaceutical after determining it has lost too much radiation between the time of the timestamp and the time for injecting the patient. ### Claim 21 A quantitative imaging system, comprising: a delivery mechanism configured to create and deliver a radiopharmaceutical to a patient to be imaged by an imaging apparatus; and a quantitative controller configured to control the delivery mechanism to create and deliver the radiopharmaceutical without human intervention. ### Claim 22 (depends on 22) The quantitative imaging system according to claim 22, wherein the delivery mechanism includes: a dose calibrator configured to sample the radiopharmaceutical for a concentration measurement of radioactive isotopes in the radiopharmaceutical and timestamps the measurement; a producer configured to convert a precursor material input into radioisotope; a synthesizer configured to synthesize the radioisotope with a biologically compatible material to form the radiopharmaceutical; an injector configured to inject the radiopharmaceutical into the subject, wherein the producer, the synthesizer, the injector and the delivery mechanism are interconnected to convey the radioisotope to the synthesizer and the radiopharmaceutical between the synthesizer, the dose calibrator and the delivery mechanism automatically without human intervention; and a quantitative analyzer configured to calculate parametric images and values from the collected data.