Reduction of background interference in a radiation image

An imaging assembly comprising:

• a radiation camera configured to obtain position-sensitive radiation data of at least one source of interest;
• a controller operatively connected to the radiation camera, the controller including a processor and tangible, non-transitory memory on which is recorded instructions for executing a method for reducing background interference in the position-sensitive radiation data in an image domain;
• wherein execution of the instructions by the processor causes the controller to:
• generate a first set of image data (G1) from the position-sensitive radiation data within a first energy window;
• generate a second set of image data (G2) from the position-sensitive radiation data within a second energy window such that the second energy window does not overlap with the first energy window;
• generate a third set of image data (G3) based at least partially on the first and second sets of image data, the third set of image data (G3) being configured to have reduced background interference;
• and
• wherein the first, second and third sets of image data are each divided into respective bins having respective numeric values.