US 2018/0017497 A1Published application

Method for measuring bismuth content in colloidal bismuth pectin or colloidal bismuth pectin-contained preparation

AssigneeShanxi Zhendong Ante Biopharmaceutical Co., Ltd.

InventorsAnping Li, Feng Cui, Ping Zhu, Zhengguo Qin, Tai Zheng, Yuexla Wu

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Abstract

Provided is a method for measuring the bismuth content in a colloidal bismuth pectin or a colloidal bismuth pectin-contained preparation. A protonic acid is used to dissociate bismuth from a colloidal bismuth pectin, the principle of the characteristic reaction between bismuth and potassium iodide to produce yellow potassium bismuth iodide is used; ultraviolet-visible spectrophotometry is for measurement; an external standard method is for calculation. The method has strong specificity, a good linear relationship, high accuracy, good repeatability and high sensitivity. The method is able to act as a quality control method for bismuth in a colloidal bismuth pectin or a colloidal bismuth pectin-contained preparation to effectively control the product quality.

Claims16

Dependent claims

A method for measuring a bismuth content in a colloidal bismuth pectin or a colloidal bismuth pectin-contained preparation, comprising steps of:

dispersing the colloidal bismuth pectin or the colloidal bismuth pectin-contained preparation into water;
adding a protonic acid dissociation agent into a dispersion until a hydrogen ion concentration reaches 0.8-1.2 mol/L;
centrifuging the dispersion after completely dissociation;
seperating a supernatant;
coloring the supernatant by adding a chromogen solution of a citric acid or an ascorbic acid and a potassium iodide to form a test solution;
testing an absorbance of the test solution at a wavelength of 380-470 nm;
comparing the absorbance of the test solution with an absorbance of a reference solution of a known bismuth concentration under same conditions;
calculating the bismuth content in the colloidal bismuth pectin or the colloidal bismuth pectin-contained preparation.

5 more elements

Dependencies are inferred from the claim text.

Facts

Application: 15/548,096Filed 27 May 2016
Priority: CN 201510348311.123 Jun 2015
Published: 18 Jan 2018
Term ends: Not estimatedThe source records don’t support an estimate.

Classification8 codes

G01N 21/78
By observing the effect on a chemical indicator: producing a change of colour
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 31/04
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics: antibacterial agents
G01N 33/84
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing:…