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AssigneeSouth China University of Technology
InventorsDawen Sun, Lina Cheng, Zhiwei Zhu, Xin'an Zeng, Qijun Wang, Zi Zhang
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The present invention discloses a method for freeze-drying drug liposomes powder assisted by a variable-frequency alternating-current electric field, which includes the following steps: (1) preparing a drug-liposome suspension sample; (2) dehydrating the sample under a 1-10 kHz, 3-10 kV high-voltage alternating current; (3) freezing and drying the sample treated in step (2) at −20° C. to −40° C., under a 10-25 kHz, 0.2-1 kV high-voltage alternating current, until completion of the freezing process; and (4) heating and drying the sample in a vacuum until completion of sublimation and desorption, and obtaining the drug liposomes freeze-dried powder. The present invention not only greatly shortens a freezing and drying time, but also controls a size of nuclei and ice crystals, further ensuring a quality of the freeze-dried powder.
A method for freeze-drying drug liposomes powder assisted by variable-frequency alternating-current electric field is provided, wherein the method comprises the following steps:
A device for freeze-drying drug liposomes powder assisted by a variable-frequency alternating-current electric field, the device comprising:
Dependencies are inferred from the claim text.