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OwnerHengli Tang, Emily M. Lee +10inventors
InventorsHENGLI TANG, EMILY M. LEE, YICHEN CHENG, YI ZHOU, WEI ZHENG, RUILI HUANG, MIAO XU, WENWEI HUANG, MENGHANG XIA, HONGJUN SONG, GUO-LI MING, ZHEXING WEN
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The present invention concerns the use of compounds for the treatment or prevention of Flavivirus infections, such as Zika virus infections. Aspects of the invention include methods for treating or preventing Flavivirus virus infection, such as Zika virus infection, by administering a compound or class of compound disclosed herein, such as a niclosamide compound, an emricasan compound, a cyclin-dependent kinase inhibitor, a proteasome inhibitor, or a combination of two or more of the foregoing, to a subject in need thereof; methods for inhibiting Flavivirus infections such as Zika virus infections in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Flavivirus infections, such Zika virus infections.
A method for treating or preventing Flavivirus infection in a human or non-human animal subject, said method comprising administering an effective amount of at least one compound to a subject in need thereof, wherein the at least one compound inhibits Flavirus infection or suppresses Flavivirus-induced caspase-3 activity, and wherein the at least one compound comprises:
A method for inhibiting Flavivirus infection in human or non-human animal cells in vitro or in vivo, said method comprising contacting an effective amount of at least one compound to a human or non-human animal cell in vitro or in vivo before or after exposure of the cell to Flavivirus, wherein the at least one compound inhibits Flavirus infection or suppresses Flavivirus-induced caspase-3 activity, and wherein the at least one compound comprises:
A composition comprising a combination of two or more of the following:
A composition comprising:
Dependencies are inferred from the claim text.