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US 2018/0008824 A1Published application
Obstructive sleep apnea treatment devices, systems and methods
AssigneeCyberonics, Inc.
InventorsStephen L. Bolea, Thomas B. Hoegh, Brian D. Kuhnley, Dale G. Suilmann, Bruce J. Persson, John P. Beck, Sidney Hauschild, Paula M. Kaplan, Adam K. Hoyhtya, Wondimeneh Tesfayesus, Robert E. Atkinson, Peter R. Eastwood, David R. Hillman
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Abstract
Devices, systems and methods of neurostimulation for treating obstructive sleep apnea.
Claims20
An implantable neurostimulation system for delivering a respiratory therapy to a subject, comprising:
- a neurostimulator adapted to deliver a neurostimulation signal to the subject, the neurostimulator comprising a microprocessor programmed to:
- titrate a stimulation setting of the neurostimulator while the subject is awake by delivering a first set of stimulation pulses at a plurality of first stimulation setting values between a lower limit defined by a capture threshold corresponding to a beneficial effect of the respiratory therapy and a first upper limit defined by a comfort threshold corresponding to a negative sensation experienced by the subject;
- and
- subsequently, when the subject is asleep, repeat the step of titrating the stimulation setting of the neurostimulator by delivering a second set of stimulation pulses at a plurality of second stimulation setting values, wherein one or more of the plurality of second stimulation setting values is different than one or more of the plurality of first stimulation setting values and the plurality of second stimulation setting values are between the lower limit defined by the capture threshold and a second upper limit defined by a threshold at which the patient is expected to at least partially arouse from sleep.
1 more element
An implantable neurostimulation system for delivering a therapy to an upper airway of a subject, comprising:
- a stimulation delivery lead configured to be implanted adjacent to a nerve stimulating an upper airway muscle of the subject;
- and
- a neurostimulator adapted to deliver a neurostimulation signal to the subject, the neurostimulator comprising a microprocessor programmed to:
- identify a stimulation operating window for the therapy, wherein the stimulation operating window includes a first threshold and a second threshold, wherein the first threshold is defined as a first level of stimulation at which a beneficial response is observed in the upper airway, and wherein the second threshold is defined as a second level of stimulation greater than the first level of stimulation, wherein the second threshold comprises an awake level at which the subject experiences a negative sensation while awake and an asleep level greater than the awake level at which the subject is expected to at least partially arouse from sleep, wherein identifying the stimulation operating window for the therapy comprises:
- titrating a stimulation setting of the neurostimulator while the subject is awake, wherein the titrating includes delivering successive stimulation bursts, via the electrode, until the first threshold and the awake level of the second threshold are identified, wherein at least one of the successive stimulation bursts includes an intensity different than another one of the successive stimulation bursts;
- and
- subsequently repeating the step of titrating the stimulation setting of the neurostimulator while the subject is asleep, wherein the repeating the step of titrating includes delivering successive stimulation bursts, via the electrode, until the asleep level of the second threshold is identified.
4 more elements
Dependencies are inferred from the claim text.