Cannula lined with tissue in-growth material

A cannula for moving blood between a pump and the circulatory system of a patient, the cannula comprising:

• a liner comprising an intermediate portion between a proximal portion and a distal portion and a lumen extending between the proximal and distal portions, wherein at least the intermediate portion is constructed from tissue in-growth material adapted to contact blood flowing through the lumen for supporting the growth of endothelial cells, the proximal portion is configured for connecting to the pump and the distal portion is configured for connecting to the circulatory system;
• a reinforcing structure surrounding at least a part of the intermediate portion of the liner for resisting kinks along the length of the cannula;
• and
• a jacket surrounding the reinforcing structure and fully encapsulating the liner;
• an outer layer surrounding at least a part of the jacket, wherein the outer layer is constructed from tissue in-growth material, the outer layer including a proximal and a distal end and an intermediate portion therebetween;
• and
• a polymeric layer extending along a partial length of the liner and the outer layer, the polymeric layer having a first portion that extends proximally from the proximal end of the outer layer to a proximal end of the cannula and a second portion that extends distally from the distal end of the outer layer to the distal end of the cannula such that the first and second portions of the polymeric layer prevent delamination of the outer layer from the jacket, the first and second portions of the polymeric layer further encapsulating the proximal and distal portions of the jacket.

An inflow cannula for moving blood from the heart of a patient to a pump, the inflow cannula comprising:

• a liner comprising an intermediate portion between a proximal portion and a distal portion and a lumen extending between the proximal and distal portions, wherein at least the intermediate portion is constructed from tissue in-growth material adapted to contact blood flowing through the lumen for supporting the growth of endothelial cells;
• wherein the distal and proximal portions are constructed from tissue in-growth material, and the distal and proximal portions of the liner have respective outer diameters that are greater than an outer diameter of the intermediate portion of the liner so as to define a channel at the intermediate portion;
• an intermediate polymeric layer disposed in the channel;
• a jacket fully encapsulating the intermediate polymeric layer;
• a tip coupled to the distal portion and configured to be inserted through a wall of the heart;
• and
• a hub coupled to the proximal portion and configured to secure the inflow cannula to the pump.

An outflow cannula for moving blood from a pump to the circulatory system of a patient, the outflow cannula comprising:

• a liner comprising an intermediate portion between a proximal portion and a distal portion and a lumen extending between the proximal and distal portions, wherein at least the intermediate portion is constructed from tissue in-growth material adapted to contact blood flowing through the lumen for supporting the growth of endothelial cells;
• wherein the distal and proximal portions are constructed from tissue in-growth material, and the distal and proximal portions of the liner have respective outer diameters that are greater than an outer diameter of the intermediate portion of the liner so as to define a channel at the intermediate portion;
• an intermediate polymeric layer disposed in the channel;
• a jacket fully encapsulating the intermediate polymeric layer;
• a hub coupled to the proximal portion and configured to secure the outflow cannula to the pump;
• and
• a distal end that is configured to be coupled to the circulatory system.

A cannula for moving blood between a pump and a circulatory system of a patient, the cannula comprising:

• a liner comprising a proximal portion, a distal portion, an intermediate portion located between the proximal and distal portions, and a lumen extending between the proximal and distal portions, wherein at least the intermediate portion is constructed from tissue in-growth material adapted to contact blood flowing through the lumen for supporting the growth of endothelial cells, the proximal portion is configured for connecting to the pump and the distal portion is configured for connecting to the circulatory system;
• a jacket fully encapsulating the liner;
• wherein the distal and proximal portions are constructed from tissue in-growth material and each have an outer diameter that is greater than an outer diameter of the intermediate portion of the liner so as to define a channel at the intermediate portion;
• and
• an intermediate polymeric layer disposed in the channel.