Coated Vaso-Occlusive Device and Methods for Treatment of Aneurysms
AssigneeCarnegie Mellon University
InventorsChristopher J. Bettinger, Michael Bruce Horowitz
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Abstract
A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm. According to one example, the coating is a poly(L-lactide-co-glycolide) (PLGA) is used to release genipin to crosslink fibrin clots thereby creating more stable occlusions. Increased clotting can improve segregation of the weakened portion of the blood vessel from the rest of the vasculature and reduce the risk of recurrence.
Claims21
1-37. (canceled)
A method of creating and stabilizing a blood clot in a patient, comprising:
- inducing clot formation in a patient's vasculature;
- and
- contacting the clot with genipin or a crosslinking genipin derivative to stabilize the clot.
A vaso-occluding catheter device comprising a sheath and first and second filaments within the sheath, wherein the second filament comprises, as a core substrate or a coating thereon, genipin or a crosslinking genipin derivative.
Dependencies are inferred from the claim text.