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US 2018/0008732 A1Published application
Methods for making ultrasound contrast agents
AssigneeLantheus Medical Imaging, Inc.
InventorsSimon P. Robinson, Robert W. Siegler, Nhung Tuyet Nguyen, David C. Onthank, Tarakeshwar Vishwanath Anklekar, Charles Chester Van Kirk
Life of this patent
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Abstract
Provided herein are improved methods for preparing phospholipid formulations including phospholipid UCA formulations.
Claims20
1-16. (canceled)
A method for preparing lipid-encapsulated gas microspheres comprising
- combining DPPA, DPPC and MPEG5000-DPPE, in propylene glycol to form a phospholipid solution, the MPEG5000-DPPE selected as having a calcium concentration of less than 115 parts per million (ppm),
- combining the phospholipid solution with an aqueous solution to form a phospholipid suspension, and
- activating the phospholipid suspension with a perfluorocarbon gas to form lipid-encapsulated gas microspheres.
18-19. (canceled)
22-24. (canceled)
A method for preparing lipid-encapsulated gas microspheres comprising
- combining DPPA, DPPC and MPEG5000-DPPE in propylene glycol, in a methanol and toluene free and methyl t-butyl ether free condition, to form a phospholipid solution, wherein MPEG5000-DPPC has a calcium concentration of less than 115 parts per million (ppm),
- combining the phospholipid solution with an aqueous solution to form a phospholipid suspension, and
- activating the phospholipid suspension with a perfluorocarbon gas, to form lipid-encapsulated gas microspheres.
28-30. (canceled)
Dependencies are inferred from the claim text.