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US 2018/0008730 A1Published application
Multifunctional fluorescent and mri-active nanostructure
AssigneeWilliam Marsh Rice University
InventorsNancy J. Halas, Ciceron Ayala-Orozco, Sandra Bishnoi, Luke Henderson, Oara Neumann, Robia Pautler
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Abstract
A Magnetic Resonance Imaging (MRI) enhancement agent includes a plurality of particles, each particle including: a metal core; a dielectric shell disposed on the metal core comprising at least one MRI contrast agent; and a metal shell disposed on the exterior surface of the dielectric shell that encapsulates the dielectric shell.
Claims30
A Magnetic Resonance Imaging (MRI) enhancement agent, comprising:
- a plurality of particles, each particle comprising:
- a metal core;
- a dielectric shell disposed on the metal core comprising at least one MRI contrast agent;
- and
- a metal shell disposed on the exterior surface o the dielectric shell that encapsulates the dielectric shell.
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A method of producing a Magnetic Resonance Imaging (MRI) enhancement particle, comprising:
- coating a metal core with a dielectric to obtain a metal core with a dielectric coating;
- loading the dielectric coating with a MRI contrast agent to obtain a loaded dielectric coating;
- seeding the exterior of the dielectric coating with a metal to obtain a seeded dielectric coating;
- and
- coating the seeded dielectric coating with a metal plating solution to obtain the magnetic resonance imaging enhancement particle.
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Dependencies are inferred from the claim text.