Multimeric compounds of a kringle domain from the hepatocyte growth factor / scatter factor (hgf/sf)
AssigneesUniversite Des Sciences Et Technologies De Lille - Lille 1, Centre National De La Recherche Scientifique, Institut Pasteur de Lille, Universite De Lille 2 Droit Et Sante, Universita' Degli Studi Di Pavia
InventorsJerome VICOGNE, Oleg MELNYK, Nathalie OLLIVIER, Eric ADRIAENSSENS, Berenice LECLERCQ, Claire SIMONNEAU, Giovanni DE NOLA, Ermanno GHERARDI, Hugo DE JONGE
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Abstract
Disclosed are multimeric compounds of K1 domains from the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) being able to induce activation of the tyrosine kinase receptor MET and their uses.
Claims20
Multimeric compound comprising at least two K1 peptide domains (Kringle 1) of the Hepatocyte Growth Factor/Scatter Factor (HGF/SF) and being represented by the formula (I):
- wherein:
- m=0 or 1,
- n=0 or 1,
- K1a, K1b, and, if present, K1c and K1d are polypeptides,
- K1a and K1b and, if present, K1c and K1d contain a K1 peptide domain, said K1 peptide domain consisting of an amino acid sequence SEQ ID NO:
- 1 or of an amino acid sequence with at least 80%, preferably 90% identity to SEQ ID NO:
- 1,
- Biot represents one molecule of biotin, and Strept represents one molecule chosen among the group consisting of:
- streptavidin, avidin, neutravidin and any synthetic or recombinant derivatives thereof,
- K1a and K1b and, if present, K1c and K1d are C-terminally linked to a Biot by a covalent bond, and each Biot is linked to Strept by a non-covalent bond,
- said multimeric compound being able to induce activation of the tyrosine kinase receptor MET.
Dependencies are inferred from the claim text.