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US 2018/0008718 A1Published application
Compositions for the sustained release of anti-glaucoma agents to control intraocular pressure
AssigneesThe Johns Hopkins University, Duke University
InventorsJie Fu, Justin Hanes, Molly Walsh, David Epstein
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Abstract
Controlled release dosage formulations for the delivery of active agents, especially for treatment of eye diseases or disorders, such as glaucoma, have been developed. These provide release of the active agent, such as ECA or a derivative thereof, for an effective period of time.
Claims22
A polymeric conjugate defined by one of the following formulae
- (A-X)m—Y—((Z)o—(X)p-(A)q)n
- wherein
- A represents, independently for each occurrence, one or more anti-glaucoma agents;
- X represents, independently for each occurrence, a hydrophobic polymer segment;
- Y is absent, or represents a branch point;
- Z represents, independently for each occurrence, a hydrophilic polymer segment;
- and
- o, p, and q are independent 0 or 1;
- m is an integer between one and twenty;
- and
- n is an integer between zero and twenty, with the proviso that A is not doxorubicin when m and n are both equal to one.
8 more elements
Dependencies are inferred from the claim text.